Nakano, Taito et al. published their research in Anticancer Research in 2020 | CAS: 53902-12-8

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Application of 53902-12-8

Therapeutic effect of ethinylestradiol in castration-resistant prostate cancer was written by Nakano, Taito;Kadono, Yoshifumi;Iwamoto, Hiroaki;Yaegashi, Hiroshi;Iijima, Masashi;Kawaguchi, Shohei;Nohara, Takahiro;Shigehara, Kazuyoshi;Izumi, Koujl;Mizkami, Atsushi. And the article was included in Anticancer Research in 2020.Application of 53902-12-8 This article mentions the following:

Background/Aim: The best sequential treatment for castration-resistant prostate cancer (CRPC) remains unclear. This study evaluated the therapeutic effects of ethinylestradiol (EE) on CRPC. Patients and Methods: A total of 80 patients with CRPC, treated with 0.5-15 mg/day of EE, were retrospectively assessed. Results: The ntedian duration from the initial treatment to the beginning of EE was 48.3 mo. A decline in the prostate-specific antigen (PSA)from the baseline was noted in 60 patients (75%) and a >50% PSA decline in 27 patients (34%). The median time ofPSA progression, overall survival, and cancer-specific survival after EE were 5.60 mo, 24.00 mo, and 27.93 mo, resp. Conclusion: EE administration for CRPC showed a relatively high PSA response regardless of timing of sequential treatment. The frequency of cardiovascular adverse events was not significantly high. EE administration is a potential treatment option for CRPC. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Application of 53902-12-8).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Application of 53902-12-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics