Ugi and Passerini Reactions of Biocatalytically Derived Chiral Aldehydes: Application to the Synthesis of Bicyclic Pyrrolidines and of Antiviral Agent Telaprevir was written by Moni, Lisa;Banfi, Luca;Basso, Andrea;Carcone, Luca;Rasparini, Marcello;Riva, Renata. And the article was included in Journal of Organic Chemistry in 2015.Recommanded Product: 58644-54-5 This article mentions the following:
Lipase-mediated desymmetrization of a meso-diol (1,2-cyclopentanedimethanol) allows the synthesis of both enantiomers of some chiral aldehydes, whose behavior in Passerini and Ugi reactions has been explored. Exploiting these two complementary multicomponent reactions and coupling them with a subsequent cyclization process, the authors observed that 6 out of all 8 possible stereoisomers of peptidomimetic pyrrolidines can be obtained in good yields. The potential of these protocols has been proved by the development of a new efficient synthesis of antiviral drug telaprevir. In the experiment, the researchers used many compounds, for example, N-Cyclopropylformamide (cas: 58644-54-5Recommanded Product: 58644-54-5).
N-Cyclopropylformamide (cas: 58644-54-5) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 58644-54-5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics