A chiroptical nanoprobe for highly selective recognition of histidine enantiomers in aqueous media was written by Liu, Keyuan;Du, Ganhong;Ye, Long;Jiang, Liming. And the article was included in Sensors and Actuators, B: Chemical in 2019.COA of Formula: C11H15NO2 This article mentions the following:
Histidine is one of the essential amino acids in the human body, and the variation of its concentration in vivo has shown it to align with some liver and kidney diseases. In this work, a series of novel poly(2-oxazoline) derivatives bearing chiral pyrrolidine-triazole moieties in the side chain were designed and synthesized to serve as chem. sensors for histidine. The results demonstrated that the homopolymer HPOx2 is capable of selectively binding optically active histidine through nitrogen/Cu2+ coordination to form complexes exhibiting induced CD (ICD) signals with signs related to the absolute configuration of the guest compound Interestingly, the micelle-type nanoparticles assembled from the corresponding amphiphilic copolymer (CPOx2) gave a much stronger CD response, with an intensity five times that of its small mol.- or homopolymer counterparts. The proposed method, based on the chiroptical probe, allows for enantioselective detection of histidine in aqueous media, showing potential application in the field of biomedical assay and chiral drug synthesis. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2COA of Formula: C11H15NO2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.COA of Formula: C11H15NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics