One-pot synthesis of quinazolinones from anthranilamides and aldehydes via p-toluenesulfonic acid catalyzed cyclocondensation and phenyliodine diacetate mediated oxidative dehydrogenation was written by Cheng, Ran;Guo, Tianjian;Zhang-Negrerie, Daisy;Du, Yunfei;Zhao, Kang. And the article was included in Synthesis in 2013.Related Products of 119023-25-5 This article mentions the following:
A variety of 4(3H)-quinazolinones are synthesized conveniently in one pot from 2-aminobenzamides and aldehydes, via cyclization catalyzed by 4-toluenesulfonic acid, followed by oxidative dehydrogenation mediated by hypervalent iodine, PhI(OAc)2 (PIDA). Highlights of the described method include the synthesis of quinazolinones bearing an N-alkoxy substituent, a new application of PIDA as an efficient dehydrogenative oxidant, and mild reaction conditions. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Related Products of 119023-25-5).
2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Related Products of 119023-25-5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics