Toxicity and analgetic activity of some congeners of salicylamide was written by Way, E. Leong;Takemori, Akira E.;Smith, Glenn E. Jr.;Anderson, Hamilton H.;Brodie, Donald C.. And the article was included in Journal of Pharmacology and Experimental Therapeutics in 1953.Application of 19311-91-2 This article mentions the following:
Eighty-one congeners of salicylamide (I), with small substituted groups in various positions on the benzene ring or on the phenolic O and amino N, were evaluated in rats as to toxicity and ability to elevate the pain-response threshold to pressure stimulus. Most of the compounds appear to be central nervous system depressants and some possess marked hypnotic properties. The relation between structure and activity is discussed. 2-Allyloxybenzamide was about 3 times as potent as I. N,N-Dimethyl-3-phenyl-salicylamide, 3-phenylsalicylamide, and N-(2-hydroxy-ethyl)-3-phenylsalicylamide were less toxic and more potent than I. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Application of 19311-91-2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 19311-91-2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics