Chiral Silver Phosphate Catalyzed Transformation of ortho-Alkynylaryl Ketones into 1H-Isochromene Derivatives through an Intramolecular-Cyclization/Enantioselective-Reduction Sequence was written by Terada, Masahiro;Li, Feng;Toda, Yasunori. And the article was included in Angewandte Chemie, International Edition in 2014.Recommanded Product: 4-Bromo-N-methoxy-N-methylbenzamide This article mentions the following:
The transformation of ortho-alkynylaryl ketones I (R1 = Me, n-Pr, i-Bu, Ph, 4-BrC6H4, etc.; R2 = n-Bu, Ph, 4-MeC6H4, etc.; R3 = H, F) through a cyclization/enantioselective reduction sequence in the presence of a chiral silver phosphate catalyst afforded 1H-isochromenes II in high yields with fairly good to high enantioselectivities. An asym. synthesis of the 9-oxabicyclo[3.3.1]nona-2,6-diene framework, which has been found in some biol. active mols., is presented as a demonstration of the synthetic utility of this method. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Recommanded Product: 4-Bromo-N-methoxy-N-methylbenzamide).
4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Recommanded Product: 4-Bromo-N-methoxy-N-methylbenzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics