Phytochemical, toxicity and antihyperglycaemic effects of Zea mays Linn leaves’ extracts was written by Kotin, Lucrece Mahoutin;Assogba, Fidele Mahoudo;Akakpo, Huguette Baie;Aikpe, Judith Fifamin Ahounou;Godonou, Jean-Benoit;Dansou, Pierre Houndjovi;Gbenou, Joachim Djimon. And the article was included in Journal of Drug Delivery and Therapeutics in 2022.Application of 10238-21-8 This article mentions the following:
In the Republic of Benin, several plants, including Zea mays Linn (Z. mays) are used for the treatment of diabetes without any scientific studies showing their effectiveness. The objective of this study is to investigate the effects of Z. mays leaves’ extracts on hyperglycemic rabbits using the Oral Glucose Tolerance Test (OGTT), 2 g/kg of (D) + glucose and on hepatic glucose liberation. Phytochem. screening revealed that the plant leaves contain alkaloids, tannins, mucilage flavonoids, anthocyanin, leuco-anthocyanin, coumarins, heteroside, flavonoid, triterpenoids, steroids, reducing compounds, saponins, oses and holosides. Cytotoxity tests showed that the aqueous and ethanolic extracts were free of toxicity. The extracts have shown anti-hyperglycemic activities dependent on specific dosage and timing. The ED is 500 mg/kg for the aqueous extract and for the ethanolic extract The extracts are effective as compared with glibenclamide (reference product). Moreover, the ex vivo test conducted on the liver revealed that Z. mays aqueous extract inhibits the hepatic glucose liberation and 500 mg/kg is the most ED. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Application of 10238-21-8).
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Application of 10238-21-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics