A convenient preparation of tetrahydropteridines and tetrahydrofolate analogs. Synthesis of tetrahydro-3′,5′-dichloromethotrexate was written by Martinelli, Jack E.;Chaykovsky, Michael. And the article was included in Preparative Biochemistry in 1980.Application In Synthesis of Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate This article mentions the following:
Folic acid (I; R = OH, R1 = R2 = H), methotrexate (I; R = NH2, R1 = Me, R2 = H), and 3′,5′-dichloromethotrexate (I; R = NH2, R1 = Me, R2 = Cl) were reduced by Me2NH/borane at 20-60° to give the corresponding tetrahydropteridines II. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Application In Synthesis of Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate).
Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application In Synthesis of Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics