Solute permeation through hydrogel membranes. Hydrophilic vs. hydrophobic solutes was written by Kim, S. W.;Cardinal, J. R.;Wisniewski, S.;Zentner, G. M.. And the article was included in ACS Symposium Series in 1980.Application In Synthesis of Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate This article mentions the following:
The permeabilities of water soluble nonelectrolytes and several hydrophobic steroids in poly(2-hydroxyethyl methacrylate) hydrogel films were determined The effects of crosslinking and variations in equilibrium water content of the films, on the observed permeabilities, were investigated. For hydrophilic solutes the permeation and partition coefficients are consistent with transport via the “bulk-like” water regions of the hydrogel films. Decreases in the “bulk-like” water via copolymerization or crosslinking reduce both the partition and permeation coefficients, indicating exclusion of hydrophilic solutes from non “bulk-like” water regions. For hydrophobic solutes, permeability coefficients are smaller and partition coefficients are much larger relative to the hydrophilic solutes. For the hydrophobic solutes modelistic anal. of the permeation and partition data indicate permeation occurs predominantly be a pore-type mechanism in poly(hydroxyethyl methacrylate) and by a partition mechanism in highly crosslinked poly(hydroxyethyl methacrylate) films. The porous flux was associated with the “bulk-like” water regions of the hydrogel films and the partition flux with the collective polymer matrix, “interfacial” and “bound” water region of the films. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Application In Synthesis of Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate).
Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Application In Synthesis of Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics