Glibenclamide alters serotonin and dopamine levels in the rat striatum and hippocampus, reducing cognitive impairment was written by Zubov, Alexander S.;Ivleva, Irina S.;Pestereva, Nina S.;Tiutiunnik, Tatiana V.;Traktirov, Dmitrtii S.;Karpenko, Marina N.. And the article was included in Psychopharmacology (Heidelberg, Germany) in 2022.SDS of cas: 10238-21-8 This article mentions the following:
Glibenclamide (GD) is a widely used medical drug; therefore, identifying the mechanisms underlying its pleiotropic effects in the central nervous system is urgent. Objectives: The aim of this work was to determine the ability of GD to modulate serotonin (5-hydroxytryptamine, 5-HT) and dopamine (DA) transmission and to assess the dose-dependent effect of GD on cognitive function in rats during natural ageing. In Experiment 1, rats received 10, 25, or 50 μg/kg GD i.p. for 10 days. In Experiment 2, rats received 50 μg/kg GD i.p. for 30 days. Spatial and working memory was assessed in the MWM and Y-maze tests, resp. In both experiments, the levels of DA and 5-HT, their metabolites, and turnover rate were analyzed by HPLC-ED in the rat hippocampus and striatum. Changes in DA and 5-HT levels occurred only with a dose of 50 μg/kg GD. Therefore, in the second experiment, we administered a dose of 50 μg/kg GD. At this dose, GD prevented the development of impairments in spatial and working memory. The hippocampal concentrations of DA and DOPAC decreased, and the striatal concentrations of DA, DOPAC, 5-HT, and 5-HIAA increased. Conclusion: One of the possible mechanisms of the precognitive effect of GD is its ability to modulate monoamine transmission. Thus, in translating our results to humans, GD can be recommended as a prophylactic agent for natural ageing to reduce the risk of developing cognitive impairments. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8SDS of cas: 10238-21-8).
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 10238-21-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics