Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions was written by Wang, Hengshuai;Jiao, Shengchao;Chen, Kerong;Zhang, Xu;Zhao, Linxiang;Liu, Dan;Zhou, Yu;Liu, Hong. And the article was included in Beilstein Journal of Organic Chemistry in 2015.Computed Properties of C7H7ClN2O This article mentions the following:
A synthetic methodol. for the construction of the fused heterocyclic compounds pyrido[2,1-b]quinazolin-9(1H)-ones I(R = H, 2-OCH3, 1-F, 3-C6H5, 2,3-C4H4, etc.) and pyrrolo[2,1-b]quinazolin-9(1H)-ones II (R1 = H, 8-Cl, 5-OCH3, 6,7-C4H4, etc.) through an AgOTf-catalyzed intramol. alkyne hydroamination reaction were described. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Computed Properties of C7H7ClN2O).
6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C7H7ClN2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics