Synthesis, characterisation and catalytic studies of nano zinc oxide-alumina for displacement reaction on carbonyldiimidazole was written by Sumathi, S.;Balaganesh, M.;Balasubramanian, K. K.. And the article was included in Rasayan Journal of Chemistry in 2020.Category: amides-buliding-blocks This article mentions the following:
Nano zinc oxide supported on alumina was prepared by chem. method and calcined at 300°C. The calcined material was characterized by UV-Visible spectroscopy, Infra-Red spectroscopy, X-Ray Diffraction technique, SEM, Thermogravimetric anal. and Porosimetry. The catalytic activity studies on alumina supported zinc oxide for the synthesis of disubstituted ureas through displacement reaction on carbonyldiimidazole are hitherto unreported. Thus, alumina supported nano zinc oxide was tested for its catalytic activity in the displacement reaction of carbonyldiimidazole with cyclohexylamine. While, the above reaction when carried out at room temperature, afforded 1,3-Dicyclohexyl urea, as the sole product in 88% yield in 20 h, at 80°C, 1,3-dicyclohexyl urea was obtained in 80% yield, in 4 h. Reusable and safer catalysts, reaction at room temperature, simple workup and product with good yield and purity are the merits of this process. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Category: amides-buliding-blocks).
1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics