α-Keto Amides and 1,2-Diketones from N,N’-Dimethoxy-N,N’-dimethylethanediamide. A Synthetic and Mechanistic Investigation was written by Sibi, Mukund P.;Marvin, Mali;Sharma, Rajiv. And the article was included in Journal of Organic Chemistry in 1995.Reference of 106675-70-1 This article mentions the following:
Title diamide (MeONMeCO)2 (1), a 1,2-dicarbonyl synthon prepared from oxalyl chloride, undergoes nucleophilic displacements with Grignard reagents to provide α-keto amides in 28-90% yields. The synthon also undergoes double nucleophilic displacements with organolithium reagents to furnish sym. 1,2-diketones in 15-84% yields. A mechanism accounting for all the products from the reaction of 1 with nucleophiles has been proposed. Several control experiments were carried out to support the proposed mechanism. In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1Reference of 106675-70-1).
N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Reference of 106675-70-1
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics