Inhibition of Human Alcohol Dehydrogenases by Formamides was written by Schindler, John F.;Berst, Kristine B.;Plapp, Bryce V.. And the article was included in Journal of Medicinal Chemistry in 1998.Related Products of 58644-54-5 This article mentions the following:
Human alc. dehydrogenase (HsADH) comprises class I (α, β, and γ), class II (π), and class IV (σ) enzymes. Selective inhibitors of the enzymes could be used to prevent the metabolism of alcs. that form toxic products. Formamides are unreactive analogs of aldehydes and bind to the enzyme-NADH complex [Ramaswamy, S.; Scholze, M.; Plapp, B. V. Biochem. 1997, 36, 3522-3527]. They are uncompetitive inhibitors against varied concentrations of alc., and this makes them effective even with saturating concentrations of alcs. Mol. modeling led to the design and synthesis of a series of cyclic, linear, and disubstituted formamides. Evaluation of 23 compounds provided structure-function information and selective inhibitors for the enzymes, which have overlapping but differing substrate specificities. Monosubstituted formamides are good inhibitors of class I and II enzymes, and disubstituted formamides are selective for the α enzyme. Selective inhibitors, with Ki values at pH 7 and 25 °C of 0.33-0.74 μM, include N-cyclopentyl-N-cyclobutylformamide for HsADH α, N-benzylformamide for HsADH β1, N-1-methylheptylformamide for HsADH γ2, and N-heptylformamide for HsADH σ and HsADH β1. In the experiment, the researchers used many compounds, for example, N-Cyclopropylformamide (cas: 58644-54-5Related Products of 58644-54-5).
N-Cyclopropylformamide (cas: 58644-54-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Related Products of 58644-54-5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics