Pharmacological research on new salicylic and gentisic acid derivatives. II. Antipyretic, antialgic, antihyaluronidase, antipermeability, and antiexudative activity was written by Preziosi, P.. And the article was included in Archivio Italiano di Scienze Farmacologiche in 1955.Synthetic Route of C11H15NO2 This article mentions the following:
The various properties for all substances of part I are tabulated with the aim of evaluating their antirheumatic activity: it is concluded that N-diethylsalicylamide, o-ethoxybenzamide, and gentisamide are more active than salicylamide. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Synthetic Route of C11H15NO2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Synthetic Route of C11H15NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics