Pharmacological research on new salicylic and gentisic acid derivatives. I. Toxicity was written by Preziosi, P.. And the article was included in Archivio Italiano di Scienze Farmacologiche in 1955.Category: amides-buliding-blocks This article mentions the following:
The L.D.50 of N-diethylsalicylamide (I), o-ethoxybenzamide (II), o-diethylaminoethoxybenzamide (III), salicoyl hydrazide (IV), N-acetylsalicoyl hydrazide (V), gentisamide (VI) and diacetylgentisic acid (VII) on rats, subcutaneously, was 121, 111, 70, 10, 181, 101, and 148%, resp., that of salicylamide (VIII); and on rabbits, intravenously, 92, 106, 107, 116, 145, 212, and 139%, resp. In experiments of chronic toxicity, with doses 1.51-3.02 times the therapeutic ones, the above behavior was confirmed: I, V, VI and VII gave no unfavorable effect, VIII was toxic in 50-100 mg. doses, II inhibited rat growth. None of the above drugs affected the blood crasis. On yeast respiration, the most toxic drug was IV, followed by I and V. The influence of the different groups (carboxyl, hydrazine, acetyl) on the drug toxicity is stressed. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Category: amides-buliding-blocks).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics