Synthesis of tertiary amides from anionically activated aromatic trifluoromethyl groups was written by O’Mahony, Gavin;Pitts, Andrew K.. And the article was included in Organic Letters in 2010.Product Details of 19311-91-2 This article mentions the following:
In this paper, a novel synthesis of tertiary amides from anionically activated aromatic trifluoromethyl groups is presented. Anionically activated trifluoromethyl groups react with secondary amines under aqueous conditions to afford tertiary amides. The mechanism involves initial elimination of hydrogen fluoride by an E1cB mechanism to afford an electrophilic quinone methide- or azafulvene-type intermediate that reacts with secondary amines under aqueous conditions to afford the tertiary amide in good yield (up to 99%). In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Product Details of 19311-91-2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Product Details of 19311-91-2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics