C-H Oxygenation Reactions Enabled by Dual Catalysis with Electrogenerated Hypervalent Iodine Species and Ruthenium Complexes was written by Massignan, Leonardo;Tan, Xuefeng;Meyer, Tjark H.;Kuniyil, Rositha;Messinis, Antonis M.;Ackermann, Lutz. And the article was included in Angewandte Chemie, International Edition in 2020.Synthetic Route of C10H10F3NO2 This article mentions the following:
The catalytic generation of hypervalent iodine(III) reagents by anodic electrooxidation was orchestrated towards an unprecedented electrocatalytic C-H oxygenation of weakly coordinating aromatic amides and ketones. Thus, catalytic quantities of iodoarenes in concert with catalytic amounts of ruthenium(II) complexes set the stage for versatile C-H activations with ample scope and high functional group tolerance. Detailed mechanistic studies by experiment and computation substantiate the role of the iodoarene as the electrochem. relevant species towards C-H oxygenations with electricity as a sustainable oxidant and mol. hydrogen as the sole byproduct. Para-Selective C-H oxygenations likewise proved viable in the absence of directing groups. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Synthetic Route of C10H10F3NO2).
N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Synthetic Route of C10H10F3NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics