Synthesis and biological evaluation of N-(cyclopropyl)benzamide-benzophenone hybrids as novel and selective p38 mitogen activated protein kinase (MAPK) inhibitors was written by Heo, Jinyuk;Shin, Hanbo;Lee, Jun;Kim, Taelim;Inn, Kyung-Soo;Kim, Nam-Jung. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Recommanded Product: 4-Bromo-N-methoxy-N-methylbenzamide This article mentions the following:
A series of hybrid mols. consisting of benzophenone derivatives and N-cyclopropyl-3-methylbenzamide derivatives were synthesized and biol. evaluated as novel p38 mitogen activated protein kinase (MAPK) inhibitors. In particular, the authors found that one compound displayed potent p38α MAPK inhibitory activity (IC50 = 0.027 μM), high kinase selectivity, and significant antiinflammatory activity in THP-1 monocyte cells [i.e., human monocytic leukemia cell line]. The synthesis of the target compounds was achieved by a reaction of N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide with [(hydroxyethoxy)phenyl](bromophenyl)methanone derivatives and analogs. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Recommanded Product: 4-Bromo-N-methoxy-N-methylbenzamide).
4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 4-Bromo-N-methoxy-N-methylbenzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics