Guercio, Giuseppe et al. published their research in Organic Process Research & Development in 2008 | CAS: 106675-70-1

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Electric Literature of C6H12N2O4

Synthesis of the NK1 Receptor Antagonist GW597599. Part 1: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine was written by Guercio, Giuseppe;Bacchi, Sergio;Goodyear, Michael;Carangio, Antonella;Tinazzi, Francesco;Curti, Stefano. And the article was included in Organic Process Research & Development in 2008.Electric Literature of C6H12N2O4 This article mentions the following:

GW597599 is a NK-1 antagonist under study for treatment of CNS disorders and emesis. The initial synthetic route devised from the medicinal chem. route, used several hazardous reagents, gave low yields, and produced high levels of wastes. By targeted process of research and development, application of novel techniques, and extensive route scouting, a synthetic route for GW597599 was developed. The optimization of the first stage in the chem. synthesis of GW597599 is described: the development of a pilot-plant process for the synthesis of arylpiperazine derivative as optically pure compound The method eliminates the initial need for cryogenic conditions and copper catalysis in Grignard chem. and allows replacing the classical resolution step with a more efficient dynamic kinetic resolution, substantially enhancing the overall yield and throughput. In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1Electric Literature of C6H12N2O4).

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Electric Literature of C6H12N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics