Esfandiari, Nadia et al. published their research in Fluid Phase Equilibria in 2022 | CAS: 10238-21-8

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Product Details of 10238-21-8

Experimental and modeling investigation of Glibenclamide solubility in supercritical carbon dioxide was written by Esfandiari, Nadia;Sajadian, Seyed Ali. And the article was included in Fluid Phase Equilibria in 2022.Product Details of 10238-21-8 This article mentions the following:

Optimized production of micro and nanoparticles using the supercritical fluid technique requires information on the solubility of pharmaceutical materials in the supercritical fluid. In this article, Glibenclamide solubility in the SC-CO2 was investigated for the first time at the temperature range 0f 308-338 K and pressure range of 12-30 MPa. Under this condition, the mole fraction of Glibenclamide was determined in the range 0.8 x 10-6 to 8.03 x 10-5. Furthermore, the six empirical models (i.e. Chrastil, Bartle et al., Mendez-Santiago and Teja (MST), Sparks et al., Bian et al., Sodeifian et al.) and PR-EoS with vdW2 mixing rule were utilized to correlate the solubility The results confirmed that Sodeifian et al. and MST models exhibited the highest accuracy with resp. Radj of 0.996 and 0.9859. Finally, the total (41.65 kJ mol-1), vaporization (65.5 kJ mol-1), and solvation. (-23.85 kJ mol-1) enthalpies were estimated by Chrastil’s model and Bartle et al. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Product Details of 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Product Details of 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics