Catalyst-free oxidative N-N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO was written by Cai, Yue-Ming;Zhang, Xin;An, Cui;Yang, Ye-Fei;Liu, Wei;Gao, Wen-Xia;Huang, Xiao-Bo;Zhou, Yun-Bing;Liu, Miao-Chang;Wu, Hua-Yue. And the article was included in Organic Chemistry Frontiers in 2019.SDS of cas: 119023-25-5 This article mentions the following:
A catalyst-free method was developed to synthesize 1,2,3-benzotriazinones I [R = H, 6-Cl, 6-Br, etc.] and 1,2,3-benzothiadiazoles II [R1 = H, 6-Cl, 6-Br, etc.] from 2-amino-benzamides and 2-amino thiols. Of particular note was that the one-step synthesis route to access [1,2,3]triazolo[1,5-a]pyridines III [R2 = H, Ph, 4-ClC6H4; R3 = H, 7-Me, 7-Br] from pyridin-2-ylmethanamine was reported for the first time. This approach featured no use of catalyst, extremely mild conditions and excellent efficiency. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5SDS of cas: 119023-25-5).
2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 119023-25-5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics