Month: January 2023

Hygiene effects of bleach systems in laundry detergents was written by Sajitz, M.;Grohmann, J.. And the article was included in SOFW Journal in 2011.Application of 10543-57-4 This article mentions the following:

Due to the increasingly common habit to wash at temperatures lower than 60°C, the laundry process requires a technol. to improve the hygiene properties. Germs and fungi can survive under these conditions and may lead to malodor formation in the washing machine, on the fabrics or even lead to human infections. The use of the bleach activators TAED (Tetraacetylethylenediamine), DOBA (4-Decanoyloxybenzoic acid) and a combination of both in a powder detergent together with Sodium percarbonate (SPC) were investigated with regard to biocidal effects on bacteria, yeast and fungi. When applied in a laboratory suspension test the hydrophobic bleach activator DOBA works better than TAED on all chosen microorganisms, particularly Candida albicans and Trichophyton rubrum. The combination of DOBA and TAED in a powder detergent together with SPC shows synergistic effects and therefore delivers a powerful attack on these microorganisms. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Application of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Carboxylate-Functionalized Zeolitic Imidazolate Framework Enables Catalytic N-Formylation Using Ambient CO₂ was written by Li, Zhengyi;Li, Hu;Yang, Song. And the article was included in Advanced Sustainable Systems in 2022.Synthetic Route of C4H7NO This article mentions the following:

In this work, carboxylate-functionalized zeolitic imidazolate framework (F-ZIF-90) with good crystallinity and porosity was constructed from ZIF-90 and employed as a robust heterogeneous catalyst to boost the reductive N-functionalization of various amines with CO₂ to furnish N-formyl compounds (up to 99% yield) in the presence of PhSiH3 under an ambient environment. The imidazole carboxylate species (COO-) can not only activate hydrosilane and CO₂ to form the key intermediate formoxysilane but also activate amines to participate in the N-formylation reaction to obtain the target product. Moreover, it can enhance the catalyst capture and exchange ability toward ambient CO₂. The powerful adsorption capacity of the F-ZIF-90 catalyst toward CO₂ was conducive to elevating CO₂ concentration around the active species. Theor. calculations showed that the carboxylate-mediated conversion path undergoes the transition state of hydrosilane activation with a relatively lower energy barrier (ΔG = 26.9 kcal mol^-1). F-ZIF-90 exhibited good thermochem. stability with no obvious activity attenuation after repeated use 5 times. This strategy opens a new avenue based on ZIFs to develop heterogeneous catalysts for reductive upgrading of CO₂. In the experiment, the researchers used many compounds, for example, N-Cyclopropylformamide (cas: 58644-54-5Synthetic Route of C4H7NO).

N-Cyclopropylformamide (cas: 58644-54-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Synthetic Route of C4H7NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Oxidative degradation of fentanyl in aqueous solutions of peroxides and hypochlorites was written by Qi, Lihong;Cheng, Zhenxing;Zuo, Guomin;Li, Shanmao;Fan, Qiping. And the article was included in Defence Science Journal in 2010.Category: amides-buliding-blocks This article mentions the following:

Fentanyl widely used in clinics as practices is potentially utilized as an incapacitant in countering terrorism and its analogs would be used as an addictive drug, so the degradation of these compounds need to be investigated for protecting environment and human health. The degradation of fentanyl was examined in a series of oxidant aqueous solutions The degradation pathways of fentanyl in the oxidant solution are discussed according to all products identified by GC/MS and LC/MS. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Insights into novel copper sulfide/percarbonate/tetraacetylethylenediamine process for sulfamethazine degradation in alkaline medium was written by Li, Yangju;Dong, Haoran;Xiao, Junyang;Li, Long;Chu, Dongdong;Hou, Xiuzhen;Xiang, Shuxue;Dong, Qixia. And the article was included in Journal of Hazardous Materials in 2022.Synthetic Route of C10H16N2O4 This article mentions the following:

This work presents a novel CuS/percarbonate/tetraacetylethylenediamine (CuS/SPC/TAED) process for the degradation of sulfamethazine (SMT). Results indicated that the CuS/SPC/TAED process enabled the efficient generation of peracetic acid (PAA), which can be efficiently activated by CuS in alk. reaction media, and 93.6% of SMT was degraded in 30 min. Mechanism study revealed that the available reactive oxygen species (ROS) including hydroxyl radical (•OH), carbonate radical (CO^•-₃), superoxide radical (O^•-₂), singlet oxygen (1O2), and organic radicals (R-O•). Among them, R-O• (acetyloxyl radical (CH₃CO•2) and acetylperoxyl radical (CH₃CO•3)) were confirmed to be the primary species that contributed to SMT degradation Simultaneously, the role of sulfur species and carbonate ions were explored. It was found that the reductive O•-2 and sulfur species rendered the efficient redox of Cu species. Besides, the effects of key influencing factors including SPC/TAED mole ratio, CuS dosage, initial pH, temperature, and nontarget matrix constituents on SMT degradation were examined Finally, the degradation intermediates of SMT was identified, and the toxicity of these products was estimated by quant. structure-activity relationship (QSAR) anal. Overall, this work offers a new and simple strategy for antibiotic-polluted water remediation. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Synthetic Route of C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Synthetic Route of C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In Vitro Cytotoxic Activity of Clinacanthus nutans Leaf Extracts Against HeLa Cells was written by Haron, Nor Hasyimah;Toha, Zaleha Md;Abas, Rafedah;Hamdan, Mohammad Razak;Azman, Nizuwan;Khairuddean, Melati;Arsad, Hasni. And the article was included in Asian Pacific Journal of Cancer Prevention in 2019.Related Products of 2387-23-7 This article mentions the following:

This study was conducted to investigate the antiproliferative activity of extracts of Clinacanthus nutans leaves against human cervical cancer (HeLa) cells. C. nutans leaves were subjected to extraction using 80% methanol or water. The methanol extract was further extracted to obtain hexane, dichloromethane (DCM), and aqueous fractions. The antiproliferative activity of the extracts against HeLa cells was determined The most cytotoxic extract was furthered analyzed by apoptosis and cell cycle assays, and the phytochem. constituents were screened by gas chromatog.-mass spectrometry (GC-MS). All of the extracts were antiproliferative against HeLa cells, and the DCM fraction had the lowest IC 50 value of 70 μg/mL at 48 h. Microscopic studies showed that HeLa cells exposed to the DCM fraction exhibited marked morphol. features of apoptosis. The flw cytometry study also confimed that the DCM fraction induced apoptosis in HeLa cells, with cell cycle arrest at the S phase. GC-MS anal. revealed the presence of at least 28 compounds in the DCM fraction, most of which were fatty acids. The DCM fraction obtained using the extraction method described herein had a lower IC50 value than those reported in previous studies that characterized the anticancer activity of C. nutans against HeLa cells. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One-pot synthesis of quinazolinones from anthranilamides and aldehydes via p-toluenesulfonic acid catalyzed cyclocondensation and phenyliodine diacetate mediated oxidative dehydrogenation was written by Cheng, Ran;Guo, Tianjian;Zhang-Negrerie, Daisy;Du, Yunfei;Zhao, Kang. And the article was included in Synthesis in 2013.Related Products of 119023-25-5 This article mentions the following:

A variety of 4(3H)-quinazolinones are synthesized conveniently in one pot from 2-aminobenzamides and aldehydes, via cyclization catalyzed by 4-toluenesulfonic acid, followed by oxidative dehydrogenation mediated by hypervalent iodine, PhI(OAc)₂ (PIDA). Highlights of the described method include the synthesis of quinazolinones bearing an N-alkoxy substituent, a new application of PIDA as an efficient dehydrogenative oxidant, and mild reaction conditions. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Related Products of 119023-25-5).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Related Products of 119023-25-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

α-Aminoamides as ligands in Goldberg amidations was written by Mitra, Aurpon W.;Hansen, Marvin M.;Laurila, Michael E.;Kolis, Stanley P.;Martinelli, Joseph R.. And the article was included in Tetrahedron Letters in 2013.Name: N,N-Diethylsalicylamide This article mentions the following:

α-Aminoamides are shown to be useful as ligands in Goldberg amidations. A number of α-aminoamides are examined and the importance of substitution on the α-aminoamides is explored. Acetamide is focused on as the nucleophilic coupling partner due to its low cost, stability and convenience as a protecting group. The initial substrate scope for these catalysts is explored and includes electronically activated and deactivated aryl bromides, however o-substituted aryl bromides are problematic. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Name: N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Name: N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Spatial distribution of dopamine, methotrexate and antipyrine during continuous intracerebral microperfusion was written by Sendelbeck, S. Lee;Urquhart, John. And the article was included in Brain Research in 1985.Reference of 7413-34-5 This article mentions the following:

The spatial distributions of 3 radiolabeled model drugs, dopamine  [51-61-6] as the hydrochloride (DA), Na methotrexate (MTX) [7413-34-5] and antipyrine (AP) [60-80-0], were determined after 6 days’ continuous microperfusion of the diencephalon of rabbits. The basic pattern of distribution was the same for each drug: the tissue concentration, expressed as a function of the perfusate concentration, was maximal at the cannula tip, and declined sharply with radial distance from the tip. However, at any given distance, concentrations of radioisotopes derived from DA and MTX, both ionized, lipid-insoluble drugs, were 1-2 orders of magnitude higher than those derived from AP, a lipid-soluble drug. Although concentrations of isotopes derived from DA and MTX were in the same range, their distribution patterns were consistently different. Intracerebrally microperfused drugs may thus have quant. different spatial distributions, related to their physicochem. characteristics and(or) their binding and metabolism in brain tissue. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Reference of 7413-34-5).

Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Reference of 7413-34-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I_Kur Inhibitor was written by Finlay, Heather J.;Johnson, James A.;Lloyd, John L.;Jiang, Ji;Neels, James;Gunaga, Prashantha;Banerjee, Abhisek;Dhondi, Naveen;Chimalakonda, Anjaneya;Mandlekar, Sandhya;Conder, Mary Lee;Sale, Harinath;Xing, Dezhi;Levesque, Paul;Wexler, Ruth R.. And the article was included in ACS Medicinal Chemistry Letters in 2016.Application of 54166-95-9 This article mentions the following:

A new series of phenylquinazoline inhibitors of K_v 1.5 is disclosed. The series was optimized for K_v 1.5 potency, selectivity vs. hERG, pharmacokinetic exposure, and pharmacodynamic potency. 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine (13k) was identified as a potent and ion channel selective inhibitor with robust efficacy in the preclin. rat ventricular effective refractory period (VERP) model and the rabbit atrial effective refractory period (AERP) model. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Application of 54166-95-9).

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 54166-95-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Copper-catalyzed cross-coupling of amides and potassium alkenyltrifluoroborate salts: a general approach to the synthesis of enamides was written by Bolshan, Yuri;Batey, Robert A.. And the article was included in Tetrahedron in 2010.Computed Properties of C6H13NO3 This article mentions the following:

Potassium alkenyltrifluoroborate salts undergo coupling with amides to give enamides using a catalytic amount of Cu(OAc)₂ under mild oxidative conditions. The air and water stable alkenyltrifluoroborate salts offer a practical alternative to the use of alkenyl halides and alkenylboronic acids as cross-coupling partners. A range of amides participate in the cross-coupling, including heterocyclic amides, imides, carbamates, benzamides, and acetamides. Optimization studies established two sets of conditions, best suited to either high pK_a or low pK_a amide substrates. Lower pK_a amide substrates worked best using a dichloromethane solvent system in the presence of 4 Å mol. sieves, 10 mol % Cu(OAc)₂, and 20 mol % N-methylimidazole. Higher pK_a amide substrates worked best using a ligandless protocol using a 1:1 dichloromethane/DMSO solvent system in the presence of 4 Å mol. sieves and 10 mol % Cu(OAc)₂. The cross-coupling reactions occur stereospecifically with retention of alkene configuration from the alkenyltrifluoroborate salt. The mild reaction conditions employed are tolerant of various functionalities, including nitro, acetals, alkyl and aryl halides, and α,β-unsaturated carbonyls. Finally, the importance of copper sources and the presence of minor impurities were investigated. In the experiment, the researchers used many compounds, for example, 2,2-Diethoxyacetamide (cas: 61189-99-9Computed Properties of C6H13NO3).

2,2-Diethoxyacetamide (cas: 61189-99-9) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Computed Properties of C6H13NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics