Month: December 2022

Monty, Olivier B. C. published the artcileHomogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries, Related Products of amides-buliding-blocks, the publication is ACS Combinatorial Science (2020), 22(2), 80-88, database is CAplus and MEDLINE.

Reaction heterogeneity, poor pH control, and catalyst decomposition in the ring-closing metathesis (RCM) of DNA-chem. conjugates lead to poor yields of the cyclized products. Herein we address these issues with a RCM reaction system that includes a novel aqueous solvent combination to enable reaction homogeneity, an acidic buffer system which masks traditionally problematic functional groups, and a decomposition-resistant catalyst which maximizes conversion to the cyclized product. Addnl., we provide a systematic study of the substrate scope of the on-DNA RCM reaction, a demonstration of its applicability to a single-substrate DNA-encoded chem. library that includes sequencing anal., and the first successful stapling of an unprotected on-DNA [i, i+4] peptide.

ACS Combinatorial Science published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mustafayev, Nazim published the artcileSynthesis and Study of Novel Derivatives of 1,3-Dioxolane as Anti-Seizing Additives to Lubricating Oils, Recommanded Product: 2-Chloroacetamide, the publication is Chemistry Africa (2022), 5(4), 821-826, database is CAplus.

The paper is focused on synthesis and study of novel derivatives of 1,3-dioxolane as anti-seizing additives to lubricating oils. By reacting 23, 2-dimethyl-4-hydroxymethyl-1,3-dioxolane with -chlorohydroxymethylchloroacetamide, 2,2-dimethyl-4-chloromethylcarbamoylmethyl-1,3-dioxolane was synthesized by reacting it with potassium S-butylxanthate and N,N-sodium diethylcarbamate synthesized 2,2-dimethyl-4-xantogenatomethylcarbamoylmethyloxymethyl-1,3-dioxolane and 2,2-dimethyl-4-N,N-diethylcarbamatomethylcarbamoylmethyloxymethyl-1,3-dioxolane, resp. The structure of all synthesized compounds was proved by studying their physicochem. properties including the defermination of refractive indexes, sp. gr. and the calculation on their basis of mol. refraction (MRD calculate and MRD found.) with their subsequent comparison, elemental composition and IR spectroscopy. The anti-seize properties of the synthesized compounds were studied using a four-ball friction machine (FFM-1). It was found that the synthesized compounds have high extreme pressure properties in synthetic (penta erythritol ether – PEE) and compounded (SN-1200 gear oil and PEE synthetic oil taken 1:1) oils and can be used to make prototypes of synthetic gear oils used in various gears. Using 2,2-dimethyl-4-xantogenatomethylcarbamoylmethyloxymethyl-1,3-dioxolane as an example, the advantage of using a compounded oil to achieve higher extreme properties is shown. The dependence of the efficiency of the lubricating properties of the synthesized compounds on their structure was revealed.

Chemistry Africa published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Recommanded Product: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics