Month: December 2022

Antibacterial action of quinone derivatives was written by Hirose, Kazuo;Kitamura, Jiro;Ose, Yoki;Mishima, Toshie. And the article was included in Ann. Proc. Gifu Coll. Pharm. in 1955.HPLC of Formula: 1146-43-6 This article mentions the following:

Fourteen derivatives of R’O₂SN:C.CH:CR.C(:O).CH:CH (I) and 1,2,4-HO(R)(R’O₂SNH)C₆H₃ were synthesized and their antibacterial properties were tested. Following compounds were comparatively effective for Staphylococcus pyogenes var. aureus and S. albus, R, R’ given: H, Ph; H, 4-MeC₆H₄; H, 3-NO₂C₆H₄; and H, 3,4-Ac(HO)C₆H₃ of the I type. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6HPLC of Formula: 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.HPLC of Formula: 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Implementation of Chemometric Tools To Improve Data Mining and Prioritization in LC-HRMS for Nontarget Screening of Organic Micropollutants in Complex Water Matrixes was written by Hohrenk, Lotta L.;Vosough, Maryam;Schmidt, Torsten C.. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2019.COA of Formula: C13H24N2O This article mentions the following:

One of the most critical steps in nontarget screening of organic micropollutants (OMP) in complex environmental samples is handling of massive data obtained from liquid chromatog. coupled with high-resolution mass spectrometry (LC-HRMS). Multivariate chemometric methods have brought about great progress in processing big data obtained from high-dimensional chromatog. systems. This work aimed at a comprehensive evaluation of two LC-Q-Orbitrap mass spectrometry full-scan data sets for target and nontarget screening of OMPs in drinking and wastewater samples, resp. For each data set, following segmentation in the chromatog. dimension, at first multivariate curve resolution alternating least-squares (MCR-ALS) was employed for simultaneous resolution of global matrixes. The chromatog. peaks and the corresponding mass spectra of OMP were fully resolved in the presence of highly coeluting irrelevant and interfering peaks. Then partial least-squares-discriminant anal. was conducted to investigate the behavior of MCR-ALS components in different water classes and selection of most relevant components. Further prioritization of features in wastewater before and after ozonization and their reduction to 24 micropollutants were then obtained by univariate statistics. Two-way information retrieved from MCR-ALS of LC-MS¹ data was also used to choose common precursor ions between recovered and measured data through data-dependent acquisition. MS¹ and MS² spectral features were used for tentative identification of prioritized OMPs. This study indicates that the described strategy can be used as a promising tool to facilitate both feature selection through a reliable classification and interference-free identification of micropollutants in nontargeted and class-wise environmental studies. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7COA of Formula: C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.COA of Formula: C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tranilast attenuates methotrexate-induced renal and hepatic toxicities: Role of apoptosis-induced tissue proliferation was written by Gamal Helal, Manar;Said, Eman. And the article was included in Journal of Biochemical and Molecular Toxicology in 2020.Computed Properties of C18H17NO5 This article mentions the following:

Drug-induced organ toxicity is a frequently encountered obstacle in the field of medical practice that limits the use of numerous pharmacol. valuable drugs. Methotrexate (MTX)-induced organ toxicity is unfortunately the rate-limiting factor for its clin. application. In the current study, MTX injection induced significant renal and hepatic toxicities manifested on functional, biochem., and histopathol. scales. This was associated with a significant elevation in both renal and hepatic contents of TNF-related apoptosis-inducing ligand (TRAIL) and caspase-8, biomarkers of tissue apoptosis. Inline, immunohistochem. anal. confirmed that tissue increased expression of Ki67 as a biomarker of tissue regeneration in both organs. Tranilast (TRAN) is a small mol. weight anti-inflammatory and antiallergic agent. TRAN’s coadministration with MTX in the current study induced a significant tissue recovery via modulation of TRAIL/caspase-8 signaling and modulation of apoptosis-induced tissue proliferation confirmed by quantification of Ki67 expression. In conclusion, TRAN can be proposed as an effective drug to attenuate MTX-induced organ toxicity via modulation of apoptosis-induced tissue proliferation pathway. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Computed Properties of C18H17NO5).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Computed Properties of C18H17NO5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Identification of the novel N-phenylbenzenesulfonamide derivatives as potent HIV inhibitors was written by Sun, Yong;Lu, Cui-Lin;Wang, Chang-Yuan;Wang, Rui-Rui;Liu, Ke-Xin;Yang, Liu-Meng;Zhen, Yu-Hong;Zhang, Hou-Li;Wang, Chao;Zheng, Yong-Tang;Ma, Xiao-Dong. And the article was included in Chinese Chemical Letters in 2015.Synthetic Route of C7H10N2O2S This article mentions the following:

Searching for more safe and effective agents for HIV treatments is still an urgent topic worldwide. Based on our continuous modifications on the benzophenone derivatives as HIV-1 reverse transcriptase (RT) inhibitors, a new template bearing N-phenylbenzenesulfonamide (PBSA) structure was designed to enhance the interactions with HIV-1 RT. In this manuscript, a series of PBSA derivatives were synthesized and evaluated for their anti-HIV-1 activity. The preliminary test showed that these compounds were potent to inhibit wild-type HIV-1 with EC₅₀ values ranging of 0.105-14.531 μmol/L. In particular, compound 13f not only has high anti-HIV-1 activity (0.108 μmol/L), but also possesses low toxicity with a TI value of 1816.6. Furthermore, the major interactions of the inhibitor 13f with HIV-1 RT were also investigated using the mol. modeling. Our discovered structure-activity relationships (SARs) of these analogs may serve as an important clue for further optimizations. In the experiment, the researchers used many compounds, for example, 4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4Synthetic Route of C7H10N2O2S).

4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Synthetic Route of C7H10N2O2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A Potential Alternative to Polystyrene: Ring-opening Terpolymerization of Different Epoxides with Phthalic Anhydride Using Metal-free Dual Catalysts was written by Lin, Li-Miao;Xu, Yong-Hang;Shen, Man;Liang, Jia-Xin;Wang, Shuan-Jin;Xiao, Min;Meng, Yue-Zhong. And the article was included in Chinese Journal of Polymer Science in 2021.Computed Properties of C13H24N2O This article mentions the following:

A series of semi-aromatic polyesters named as Poly(PO-CHO-PA) were facilely synthesized via ring-opening terpolymn. of bio-based cyclohexane oxide (CHO)/propylene oxide (PO)/phthalic anhydride (PA) using economical U1/PPNCl as dual catalyst. The proportion of CHO-PA and PO-PA segments in polymer can be readily altered by changing the feed ratio of CHO/PO because the reactivity ratios of CHO and PO with PA calculated by Fineman-Ross method are comparable. All synthesized amorphous polyesters with various compositions show one Tg ranging from 62°C to 133°C. Significantly, the mech., thermal and barrier properties of these amorphous semi-aromatic polyesters are also adjustable and investigated for the first time. The results indicate the semi-polyesters exhibit superior thermostability (T5% ranging from 306°C to 323°C) and high tensile strength (40.21-55.7 MPa) that is comparable with polystyrene (PS). Furthermore, Poly(PO-CHO-PA) films possess a promising prospect as packaging materials because of its colorless and highly transparent nature, along with low oxygen and water vapor transmission rate. All above performances may guarantee its potential alternative to com. PS. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Computed Properties of C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Computed Properties of C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Visible-Light-Promoted Carboimination of Unactivated Alkenes for the Synthesis of Densely Functionalized Pyrroline Derivatives was written by Cai, Sai-Hu;Xie, Jia-Hao;Song, Shengjin;Ye, Lu;Feng, Chao;Loh, Teck-Peng. And the article was included in ACS Catalysis in 2016.Quality Control of N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide This article mentions the following:

An efficient strategy which integrates visible-light-induced iminyl-radical formation with carboimination of unactivated alkenes has been developed for the easy access of densely functionalized pyrroline derivatives With fac-[Ir(ppy)₃] as photoredox catalyst, the acyl oximes were converted into iminyl radical intermediates by one electron reduction, and evolve through a cascade of intramol. cyclization and intermol. carbon radical trapping to give the functionalized pyrrolines. The utilization of silyl enol ethers as coupling partners not only allows the introduction of synthetically useful ketone functionalities but also renders catalyst regeneration without any external reductants. This protocol is characterized by its mild reaction conditions and the tolerance of a broad range of functionalities. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Quality Control of N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Quality Control of N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bleaching of modal/AN-g-casein fiber blend with H₂O₂/TAED activating system was written by Li, Qing;Tang, Hui;Tang, Ren-Cheng. And the article was included in Journal of Applied Polymer Science in 2012.COA of Formula: C10H16N2O4 This article mentions the following:

The bleaching of modal/AN-g-casein fiber blend using hydrogen peroxide/tetraacetylethylenediamine (H₂O₂/TAED) activating system was investigated, and the influence of key factors on bleaching was determined The whiteness index of bleached fabrics was greatly affected by sodium carbonate and H₂O₂/TAED dosages, and the dyeability of bleached fabrics with acid dyes was greatly dependent on H₂O₂/TAED dosages and bleaching temperature Compared with the conventional H₂O₂ bleach under alk. conditions, the activated bleach markedly decreased the loss of casein in AN-g-casein fiber due to its acidic conditions, and exhibited the advantages of energy saving and high efficiency. However, the fabrics bleached using the activated process had the poor acidic dyeing properties due to the oxidation of amino groups in AN-g-casein fiber. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4COA of Formula: C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.COA of Formula: C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Iminyl radical-triggered relay annulation for the construction of bridged aza-tetracycles bearing four contiguous stereogenic centers was written by Jiang, Kun;Li, Shi-Jun;Liu, Qing-Peng;Yu, Ning;Li, Yu-Lin;Zhou, Yu-Qiang;He, Kui-Cheng;Lin, Jing;Zheng, Ting-Yu;Lang, Jian;Lan, Yu;Wei, Ye. And the article was included in Chemical Science in 2022.Electric Literature of C10H10F3NO2 This article mentions the following:

An unprecedented, iminyl radical-triggered relay annulation from oxime-derived peresters and azadienes, which showed good substrate scope and functional group compatibility, and could deliver various bridged I [X = CH₂, O; R¹ = Ph, 4-methylphenyl, 4-methoxyphenyl, etc.] and II [R² = Ph, 3-methylphenyl, 4-methoxyphenyl; R³ = propan-2-yl, Bu, hexan-2-yl, etc.] with complex mol. topol. and four contiguous stereogenic centers (dr > 19 : 1) in a single operation. This transformation represented the first example of trifunctionalization of iminyl radicals through simultaneous formation of one C-N and two C-C bonds. DFT calculation studies were conducted to obtain an in-depth insight into the reaction pathways, which revealed that the reactions involved an interesting 1,6-hydrogen atom transfer process. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Electric Literature of C10H10F3NO2).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C10H10F3NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Preparation of ο-(n-hexylthio)benzamides and tests for their fungistatic action was written by Ponci, R.;Gialdi, F.;Baruffini, A.. And the article was included in Farmaco, Edizione Scientifica in 1959.Formula: C11H15NO2 This article mentions the following:

Adding to 0.5 mole thiosalicylic acid in 350 cc. EtOH at 60° 1 mole NaOH in 250 cc. water and 0.6 mole n-C₆H₁₃Br in 300 cc. EtOH and 1 g. KI in 10 cc. water, heating at 100° 2 hrs. in a steam of N, diluting with 1 l. water, cooling, filtering with a small amount of C, acidifying with dil HCl in the cold, keeping 1 hr. on ice, filtering, and washing with water gave 92% ο-(n-C₆H₁₃S)C₆H₄CO₂H (I), m. 96-7° (95% EtOH). Treating 0.2 mole I with 0.5 mole SOCl₂ 4 hrs. gave the chloride of I, b₃ 175-8°. Dropping 0.02 mole I chloride in 40 cc. Et₂O at 0° into 40 cc. Et₂O containing 0.05 mole NH₃, keeping some hrs. at room temperature, evaporating to half volume in vacuo, filtering, and washing the solid first with cold. Et₂O then with ice water gave I amide, m. 103-4° (95% EtOH). Using BuNH₂ in place of NH₃ gave the Bu amide (II) of I, m. 49-50° (ligroine). Adding 0.04 mole I chloride in 60 cc. dioxane to 0.08 mole thiourea in 80 cc. dioxane, refluxing 15 min., keeping 1 hr. at room temperature, evaporating in vacuo, and extracting the residue with Et₂O gave after washing, drying, and evaporating I thioureide, m. 98-9° (95% EtOH). Using benzylamine and proceeding as for II gave the benzylamide of I, m. 81-2° (EtOH); PhNH₂ gave the anilide of I, m. 73-4° (80% EtOH). The β-naphthylamide of I m. 94° (95% EtOH), p-chloroanilide m. 86-7° (EtOH and ligroine), p-methylanilide of I m. 84-5° (AcOH and EtOH). None of the compounds was active against Candida albicans and only I and II were active against Trichophyton mentagrophytes. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Formula: C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Formula: C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ligand-Promoted Alkynylation of Aryl Ketones: A Practical Tool for Structural Diversity in Drugs and Natural Products was written by Xu, Hui;Ma, Biao;Fu, Zunyun;Li, Han-Yuan;Wang, Xing;Wang, Zhen-Yu;Li, Ling-Jun;Cheng, Tai-Jin;Zheng, Mingyue;Dai, Hui-Xiong. And the article was included in ACS Catalysis in 2021.Application of 116332-61-7 This article mentions the following:

A palladium-catalyzed ligand-promoted alkynation of unstrained aryl ketones RC(O)R¹ (R = naphthalen-2-yl, 1-benzothiophen-5-yl, 4-(2H-1,2,3-triazol-2-yl)benzen-1-yl, etc.; R¹ = Me, n-Pr, Ph, etc.) have been reported. The protocol allows the alkynation to be carried out in a one-pot procedure with broad functional-group tolerance and substrate scope for the synthesis of aryl-/terminal alkynes RCCR² (R² = 2-fluorophenyl, naphthalen-2-yl, thiophen-2-yl, etc.) and RCCH. The potential applications of this protocol in drug discovery and chem. biol. are further demonstrated by late-stage diversification of a number of pharmaceuticals and natural products e.g., I. More importantly, two different biol. important fragments R³CCR⁴ (R = 3-methoxy-4-([(2S,3R,4S,5R,6R)-3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy)benzen-1-yl, 6-[3-(adamantan-1-yl)-4-methoxyphenyl]naphthalen-2-yl; R⁴ = 4-(dipropylsulfamoyl)phenyl) derived from a pharmaceutical and natural product could be connected by the consecutive alkynation of ketones CH₃(CH₂)₂C(O)R⁴. Distinct from aryl halides in conventional Sonogashira reactions, the protocol provides a practical tool for the 1,2-bifunctionalization of aryl ketone (1-[(17β)-17-(acetyloxy)estra-1,3,5(10)-trien-2-yl]ethanone) by merging ketone-directed ortho-C-H activation with ligand-promoted ipso-Ar-C(O) alkynation. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Application of 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics