Month: December 2022

Fischbach, Melanie published the artcileProtease Probes that Enable Excimer Signaling upon Scission, SDS of cas: 186046-83-3, the publication is Angewandte Chemie, International Edition (2014), 53(44), 11955-11959, database is CAplus and MEDLINE.

Peptide-based probes that fluoresce upon proteolytic cleavage are invaluable tools for monitoring protease activity. The read-out of protease activity through pyrene excimer signaling would be a valuable asset because the large Stokes shift and the long lifetime of the excimer emission facilitate measurements in autofluorescent media such as blood serum. However, proteolytic cleavage abolishes rather than installs the proximity relations required for excimer signaling. Herein, the authors introduce a new probe architecture to enable the switching on of pyrene excimer emission upon proteolytic scission. The method relies on hairpin-structured peptide nucleic acid (PNA)/peptide hybrids with pyrene units and anthraquinone-based quencher residues positioned in a zipper-like arrangement within the PNA stem. The excimer hairpin peptide beacons afforded up to a 50-fold enhancement of the pyrene excimer emission. Time-resolved measurements allowed the detection of matrix metalloprotease 7 in human blood serum.

Angewandte Chemie, International Edition published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, SDS of cas: 186046-83-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rasu, Loorthuraja published the artcileA Fortuitous, Mild Catalytic Carbon-Carbon Bond Hydrogenolysis by a Phosphine-Free Catalyst, Application of N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Australian Journal of Chemistry (2016), 69(5), 561-564, database is CAplus.

The putative catalyst trans-[Ru((S,S)-skewphos)(H)₂((R,R)-dpen)] (skewphos=2,4-bis(diphenylphosphino)pentane; dpen=1,2-diphenylethylenediamine) transforms the trifluoroacetyl amide 2,2,2-trifluoro-1-(piperidin-1-yl)ethanone under mild conditions (4 atm H₂, room temperature, 4-24h, 1 mol-% Ru, 15 mol-% KOtBu in tetrahydrofuran) to generate the formylated amine 1-formylpiperidine and fluoroform via C-C bond hydrogenolysis. Catalysts are also prepared by reacting cis-[Ru(η³-C₃H₅)(MeCN)₂(COD)]BF₄ (COD=1,5-cyclooctadiene) with diamine ligands in situ. Low-temperature NMR studies provided insight into this reaction.

Australian Journal of Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Application of N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Li, Dan published the artcileSynthesis and herbicidal activity of N-isoindoline-1,3-dione-substituted phenyl-N’-benzoyl ureas, Related Products of amides-buliding-blocks, the publication is Yingyong Huagong (2007), 36(6), 530-533, database is CAplus.

A method for the synthesis of the title compounds [i.e., N-[[[(halo)-5-(1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]amino]carbonyl]benzamide derivatives] is reported here. In search of safer and more efficiency herbicidal compounds, flumioxazin [i.e., 2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione] was chosen as lead compound and eleven N-isoindoline-1,3-dione-substituted phenyl-N’-benzoyl ureas were designed and synthesized. Their structures were confirmed by IR, NMR, LC/MC and elemental anal. A preliminary bioassay showed that most of these title compounds had better herbicidal activity than the lead compound Several compounds displayed more than 80% inhibition to broad-leaf weeds, such as Abutilon theophrasti, Chenopodium album L., Amaranthus ascendens L. at 75 g/hm².

Yingyong Huagong published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Robson, John H. published the artcileThe infrared spectra of N-substituted trifluoroacetamides, COA of Formula: C6H10F3NO, the publication is Journal of the American Chemical Society (1955), 498-9, database is CAplus.

Et₂NH (14.6 g.) in 100 cc. Et₂O cooled to -10°, treated with 14 cc. (CF₃CO)₂O, and the mixture warmed to room temperature, washed with H₂O, dried, and fractionated gave 11.7 g. CF₃CONEt₂, b₂₄ 65-7°, n_D²⁴ 1.3782. Similarly were prepared the following CF₃CONHR (R, b.p./mm., m.p., and n_D²⁵ given): iso-Pr, 71-2°/20.5, 51.0-2.3° (from hexane), -; Bu, 100-1°/28.5, -, 1.3805; and the amides CF₃CONR₂: iso-Pr, -, 52-2.5°, -; Bu, 106°/16.0, -, 1.3997; iso-Bu, 89.0-9.5°/13.4, -, 1.4017. By conventional methods were prepared the following AcNR₂ (same data given): Et, 179-81°/700, (88.5-91.0°/31.0), -, 1.4333; Pr, 94.5°/12.0, -, 1.4411; Bu, 238°/705, (116.5°/8.0), -, 1.4451. (iso-Bu)₂NH (106 cc.) added to 240 cc. purified Ac₂O, the mixture heated to 110°, and 170 cc. AcOH and excess Ac₂O distilled off yielded 75.3 g. (iso-Bu₂)NAc, b_0.8 102.5-103.0, n_D²⁵ 1.4434; it was reported previously by Chute, et al. (C.A. 42, 4919b), to be a solid, m. 74°, which was probably (iso-Bu)₂NNO₂. HCONHEt₂, b_15.0 69°, n_D²⁵ 1.4296, was prepared by the method of Ott, et al. (C.A. 37, 5014.3). (Me₂CH)₂NH (101 g.) added below 60° to 46.0 g. 98-100% HCO₂H in 200 cc. m-xylene, the mixture refluxed 48 hrs. with the H₂O of reaction removed continuously, and the homogeneous solution fractionated gave 54.0 g. HCON(CHMe)₂, b_23.5 93-3.8°, m. 11.6°, n_D²⁵ 1.4371. Similarly were prepared HCONPr₂, b₇₁₅ 206-7°, n_D²⁵ 1.4384 (could not be crystallized at -70°), and HCONBu₂, b_7.8 101°, n_D²⁰ 1.4400. The infrared absorption maximum of the compounds described are tabulated.

Journal of the American Chemical Society published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, COA of Formula: C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Simons, Sami O. published the artcileMontelukast for bronchiolitis obliterans syndrome after lung transplantation, Safety of [(2-Hexylcyclopentylidene)amino]thiourea, the publication is Chest (2012), 141(1), 275-276, database is CAplus and MEDLINE.

A review. A polemic in response to Todd and Palmer (Chest 2011, 140, 2, 502-508) is given. In their study, Todd and Palmer provided an excellent overview of the pathogenesis of bronchiolitis obliterans syndrome after lung transplantation, placing emphasis on future clin. translational treatment directions. Although their review is thorough, the authors have missed one important translational development, namely the leukotriene B4 pathway in the pathophysiol. of bronchiolitis obliterans syndrome after lung transplantation.

Chest published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C13H12BClO3, Safety of [(2-Hexylcyclopentylidene)amino]thiourea.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Herrero, A. published the artcileDetermination of dichlobenil and its major metabolite (BAM) in onions by PTV-GC-MS using PARAFAC2 and experimental design methodology, Related Products of amides-buliding-blocks, the publication is Chemometrics and Intelligent Laboratory Systems (2014), 92-108, database is CAplus.

The optimization of a GC-MS anal. procedure which includes derivatization, Quick Easy Cheap Effective Rugged and Safe (QuEChERS) and programmed temperature vaporization (PTV) using design of experiments is performed to determine 2,6-dichlorobenzonitrile (dichlobenil) and 2,6-dichlorobenzamide (BAM) in onions, using 3,5-dichlorobenzonitrile and 2,4-dichlorobenzamide as internal standards The use of a central composite design and two D-optimal designs, together with the desirability function, makes it possible to significantly reduce the economic, time and environmental cost of the study. The usefulness of PARAFAC2 for solving problems as the interference of unexpected derivatization artifacts unavoidably linked to some derivatization agents, or the presence of coeluents from the complex matrix, which share m/z ratios with the target compounds, is shown. The limits of decision (CCα) of the optimized procedure, 5.00 μg kg^– 1 for dichlobenil and 1.55 μg kg^– 1 for BAM (α = 0.05), are below the maximum residue limit (MRL) established by the EU for dichlobenil (20 μg kg^– 1) in this commodity.

Chemometrics and Intelligent Laboratory Systems published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Reddy, Y. Thirupathi published the artcileSulfamic acid: An efficient, cost-effective, and reusable solid acid catalyst for the synthesis of 1,8-naphthyridines under solvent-free heating and microwave irradiation, COA of Formula: C5H8N2O, the publication is Synthetic Communications (2008), 38(18), 3201-3207, database is CAplus.

An efficient and convenient method is described for the synthesis of 1,8-naphthyridines in excellent yields by condensation of 2-aminonicotinaldehyde with various active methylene compounds in the presence of sulfamate as the catalyst in solvent-free media using both conventional heating and microwave irradiation

Synthetic Communications published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, COA of Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Karteek, S. Durga published the artcileSynthesis and Docking Study of Novel Pyranocoumarin Derivatives, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is Russian Journal of Organic Chemistry (2021), 57(2), 272-282, database is CAplus.

A new series of fused tricyclic coumarin derivatives I [R¹ = H, Me, Ph, etc.; R² = H, Me, Et] were designed, synthesized by a simple and convenient method, starting from 4-hydroxycoumarin and virtually screened by mol. docking on the target protein 3FRZ (PDB ID: 3FRZ), a HCV RNA-dependent RNA polymerase, for potency against hepatitis C virus (HCV). Efficient binding to the target protein was found for most of the synthesized compds I.

Russian Journal of Organic Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dvorak, Thomas published the artcileSynthesis of substituted thieno[2,3-d]isothiazoles as potential plant activators, Quality Control of 360-92-9, the publication is ARKIVOC (Gainesville, FL, United States) (2013), 245-265, database is CAplus.

Thieno[2,3-d]isothiazoles were synthesized as potential plant activators. Based on previously reported thienothiadiazole plant activators, one ring nitrogen was eliminated from the bicyclic motif in order to extend structure activity relationship information. Thieno[2,3-d]isothiazoles bearing different functional groups, e.g., I (R = Me, Ph, H, CF₃), were prepared starting from readily available 3,4-dibromothiophene. Introduction of an oxime and a methylthio group in positions 1 and 2 of the thiophene system set the stage for cyclization, which occurred spontaneously after converting the oxime into the more reactive oxime ester in the presence of methanesulfonyl chloride.

ARKIVOC (Gainesville, FL, United States) published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Quality Control of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Selak, Ana published the artcileEcotoxicological aspects related to the occurrence of emerging contaminants in the Dinaric karst aquifer of Jadro and Zrnovnica springs, COA of Formula: C24H29N5O3, the publication is Science of the Total Environment (2022), 153827, database is CAplus and MEDLINE.

Karst aquifers are globally important source of drinking water and harbor specific ecosystems that are vulnerable to anthropogenic contamination. This paper provides insights into the occurrence and ecotoxicol. characterization of 21 emerging contaminants (ECs) detected in the karst catchment of Jadro and Zrnovnica springs (Dinarides, Croatia). Karst springs used for water supply, surface water, and groundwater were sampled during seven campaigns. The ECs concentration levels ranged from 0.3 ng/L (tramadol in Jadro spring) to 372 ng/L (1H-benzotriazole in Cetina River). DEET was the most frequently detected ECs with an average concentration of around 50 ng/L in both surface water and groundwater. To prioritise detected ECs, their persistence (P), bioaccumulation (B), mobility (M) and toxicity (T) were assessed based on in silico strategy for PBT assessment and recently developed REACH PMT guidelines. PBT scores ranging below the threshold of 0.5, indicated non-PBT compounds of expected low concern. However, only 4 out of 21 detected ECs were not assessed as PMT/vPvM. Concerningly, 20 ECs were categorised as very mobile. Karst springs exhibited larger proportions of ECs meeting PMT/vPvM criteria than surface water. To characterize the contamination extent and estimate the incidence of adverse effects of detected ECs, a preliminary environmental risk assessment (ERA) was conducted. Most ECs posed no environmental risk with RQ values predominantly below 0.01. The total risk quotient RQsite accentuated Cetina River as having the highest risk compared to other sampling sites. This is the first study on ECs in Croatian karst, contributing to a growing need to understand the impacts of emerging contaminants in karst aquifers, which are still largely unexplored.

Science of the Total Environment published new progress about 137862-53-4. 137862-53-4 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Angiotensin Receptor, name is (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, and the molecular formula is C6H5F4NO3S, COA of Formula: C24H29N5O3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics