Month: December 2022

Cobalt-Catalyzed Selective Unsymmetrical Dioxidation of gem-Difluoroalkenes was written by Orsi, Douglas L.;Douglas, Justin T.;Sorrentino, Jacob P.;Altman, Ryan A.. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: 1146-43-6 This article mentions the following:

Gem-Difluoroalkenes represent valuable synthetic handles for organofluorine chem.; however, most reactions of this substructure proceed through reactive intermediates prone to eliminate a fluorine atom and generate monofluorinated products. Taking advantage of the distinct reactivity of gem-difluoroalkenes, we present a cobalt-catalyzed regioselective unsym. dioxygenation of gem-difluoroalkenes using phenols and mol. oxygen, which retains both fluorine atoms and provides β-phenoxy-β,β-difluorobenzyl alcs. Mechanistic studies suggest that the reaction operates through a radical chain process initiated by Co(II)/O₂/phenol and quenched by the Co-based catalyst. This mechanism enables the retention of both fluorine atoms, which contrasts most transition-metal-catalyzed reactions of gem-difluoroalkenes that typically involve defluorination. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Recommanded Product: 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Recommanded Product: 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lewis Acid Assisted Broensted Acid Catalysed Decarbonylation of Isocyanates: A Combined DFT and Experimental Study was written by Dasgupta, Ayan;van Ingen, Yara;Guerzoni, Michael G.;Farshadfar, Kaveh;Rawson, Jeremy M.;Richards, Emma;Ariafard, Alireza;Melen, Rebecca L.. And the article was included in Chemistry – A European Journal in 2022.Formula: C13H24N2O This article mentions the following:

An efficient and mild reaction protocol for the decarbonylation of isocyanates was developed using catalytic amounts of Lewis acidic boranes. The electronic nature (electron withdrawing, electron neutral, and electron donating) and the position of the substituents (ortho/meta/para) bound to isocyanate controls the chain length and composition of the products formed in the reaction. Detailed DFT studies were undertaken to account for the formation of the mono/di-carboxamidation products and benzoxazolone compounds In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Formula: C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Formula: C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nitrosation and hydrazine derivatives. 7. Reactions of phenelzine, endralazine and procorbazine under nitrosation conditions was written by Hanefeld, Wolfgang;Hunz, Ingrid. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1992.Name: 4-Formyl-N-isopropylbenzamide This article mentions the following:

The nitrosation of phenelzine [(2-phenylethyl)hydrazine], endralazine [6-benzoyl-5,6,7,8-tetrahydropyrido[4,3-c]pyridazin-3(2H)-one 3-hydrazone] and procarbazine [N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide] was investigated and the mechanism was discussed. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Name: 4-Formyl-N-isopropylbenzamide).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Name: 4-Formyl-N-isopropylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold was written by Serafim, Ricardo A. M.;Sorrell, Fiona J.;Berger, Benedict-Tilman;Collins, Ross J.;Vasconcelos, Stanley N. S.;Massirer, Katlin B.;Knapp, Stefan;Bennett, James;Fedorov, Oleg;Patel, Hitesh;Zuercher, William J.;Elkins, Jonathan M.. And the article was included in Journal of Medicinal Chemistry in 2021.Recommanded Product: 2-(2-Chlorophenyl)acetamide This article mentions the following:

SLK (STE20-like kinase) and STK10 (serine/threonine kinase 10) are closely related kinases whose enzymic activity is linked to the regulation of ezrin, radixin, and moesin function and to the regulation of lymphocyte migration and the cell cycle. We identified a series of 3-anilino-4-arylmaleimides as dual inhibitors of SLK and STK10 with good kinome-wide selectivity. Optimization of this series led to multiple SLK/STK10 inhibitors with nanomolar potency. Crystal structures of exemplar inhibitors bound to SLK and STK10 demonstrated the binding mode of the inhibitors and rationalized their selectivity. Cellular target engagement assays demonstrated the binding of the inhibitors to SLK and STK10 in cells. Further selectivity analyses, including anal. of activity of the reported inhibitors against off-targets in cells, identified compound 31 as the most potent and selective inhibitor of SLK and STK10 yet reported. In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Recommanded Product: 2-(2-Chlorophenyl)acetamide).

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 2-(2-Chlorophenyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rapid access to diverse, trifluoromethyl-substituted alkenes using complementary strategies was written by Phelan, James P.;Wiles, Rebecca J.;Lang, Simon B.;Kelly, Christopher B.;Molander, Gary A.. And the article was included in Chemical Science in 2018.Application In Synthesis of 4-Bromo-N-methoxy-N-methylbenzamide This article mentions the following:

Two synergistic approaches to the facile assembly of complex α-trifluoromethyl alkenes are described. Using α-trifluoromethyl-β-silyl alcs. as masked trifluoromethyl alkenes, cross-coupling or related functionalization processes at distal electrophilic sites can be executed without inducing Peterson elimination. Subsequent Lewis acidic activation affords functionalized α-trifluoromethyl alkenes. Likewise, the development of a novel α-trifluoromethylvinyl trifluoroborate reagent complements this approach and allows a one-step cross-coupling of (hetero)aryl halides to access a broad array of complex α-trifluoromethyl alkenes. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Application In Synthesis of 4-Bromo-N-methoxy-N-methylbenzamide).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Application In Synthesis of 4-Bromo-N-methoxy-N-methylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and antiviral effect of p-alkylbenzenesulfonamide derivatives was written by Tsuji, Tadakazu;Kawabata, Junzo;Kobayashi, Sachiko;Ueda, Takeo. And the article was included in Chemical & Pharmaceutical Bulletin in 1964.HPLC of Formula: 1146-43-6 This article mentions the following:

p-Alkylbenzenesulfonamide derivatives were synthesized by the reaction of p-alkyl- or p-alkoxybenzenesulfonyl chloride with amine or ammonia, and the compounds were recrystallized from dilute EtOH. Lower alkyl and alkoxyl groups introduced into benzenesulfonamide gave rise to in vitro activity on poliomyelitis virus (Lansing strain). Mice were inoculated intracerebrally with poliomyelitis virus prior to intravenous injections of the tested derivative Only p-toluenesulfonamide and N-phenyl-p-toluenesulfonamide showed in vivo activity on viral multiplication. N-Phenyl-p-toluenesulfonamide required repeated daily administrations of 11 mg./kg. for 3-5 days to demonstrate effectiveness. None of the derivatives was effective against Japanese encephalitis (Nakayma strain) or influenza A virus (PR-8 strain). In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6HPLC of Formula: 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.HPLC of Formula: 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Effect of sikkam (Bischofia javanica Blume) ethanolic extract on the quality and quantity of hyperglycemic rat sperm was written by Ilyas, Syafruddin;Hutahaean, Salomo;Sinaga, Rahmat S. H.;Situmorang, Putri C.. And the article was included in Journal of Pharmacy & Pharmacognosy Research in 2022.Reference of 10238-21-8 This article mentions the following:

Context: Hyperglycemia causes diabetes mellitus (DM), abnormal metabolism, oxidative stress, and chronic complications such as impotence. Hyperglycemia causes testicular atrophy and stromal cell, seminiferous tubular damage, and spermatogenic cells. Bischofia javanica Blume is a plant that is used for the treatment of various chronic conditions and has traditionally by the people of Indonesia as a diabetes medicine. Aims: To determine the effect of B. javanica extract on the increase in the quality and quantity of sperm of hyperglycemic rats. Methods: The treatment groups consisted of; G0: neg. control (-), G1: pos. control (DM: alloxan induction + standard feed), G2-G4: DM + 300, 600 and 900 mg/kg BW of B. javanica leaves ethanol extract, resp., and G5: DM + glibenclamide 0.5 mg/kg BW. Rats were dissected, and then the testes were taken to analyze sperm quantity and quality and immunohistochem. Results: There was a significant difference (p<0.05) in testes volume, sperm concentration and sperm motility in hyperglycemic rats. The decrease in caspase 3 expression and apoptosis was accompanied by an increase in the dose of the highest B. javanica ethanol extract, and it was seen that testicular histol. in groups G4 (900 mg/kg) and G5 (glibenclamide) could improve testicular histol. like in the control group (G0). Conclusions: B. javanica can improve the quality and quantity of hyperglycemic rats’ sperm and also reduce apoptosis via caspase 3 in the histol. of testis. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Reference of 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Reference of 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Innovative bleaching active system which could improve bleaching performance was written by Song, Rong-hua. And the article was included in Zhongguo Xidi Yongpin Gongye in 2013.Recommanded Product: 10543-57-4 This article mentions the following:

An effective low temperature bleaching active granule Peractive Perfect Clean (PPC) was developed based on TAED, which contains tetraacetylethylenediamine (TAED) and decanoyloxy benzoate (DOBA). Compared with TAED, low temperature stain removing effect, especially removing oil stain, of PPC was more effective. DOBA was gentler to color than TAED. PPC could effectively sterilize at 20°C. Soaking under 21°C for 15°C, the degerming abilities of PPC on Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans and Trichophyton rubrum were the highest, and the removal rate on Trichophyton rubrum reached 99.9%. Peractive PPC could effectively improve the comprehensive performance of the laundry products. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Recommanded Product: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ni-Catalyzed asymmetric reduction of α-keto-β-lactams via DKR enabled by proton shuttling was written by Wang, Fangyuan;Tan, Xuefeng;Wu, Ting;Zheng, Long-Sheng;Chen, Gen-Qiang;Zhang, Xumu. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Electric Literature of C11H13NO2 This article mentions the following:

Chiral α-hydroxy-β-lactams are key fragments of many bioactive compounds and antibiotics, and the development of efficient synthetic methods for these compounds is of great value. The highly enantioselective dynamic kinetic resolution (DKR) of α-keto-β-lactams was realized via a novel proton shuttling strategy. A wide range of α-keto-β-lactams were reduced efficiently and enantioselectively by Ni-catalyzed asym. hydrogenation, providing the corresponding α-hydroxy-β-lactam derivatives with high yields and enantioselectivities (up to 92% yield, up to 94% ee). Deuterium-labeling experiments indicate that phenylphosphinic acid plays a pivotal role in the DKR of α-keto-β-lactams by promoting the enolization process. The synthetic potential of this protocol was demonstrated by its application in the synthesis of a key intermediate of Taxol and (+)-epi-Cytoxazone. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Electric Literature of C11H13NO2).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Electric Literature of C11H13NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of α-arylcarboxylic acid amides from silyl enol ether via migratory amidation with 2-azido-1,3-dimethylimidazolinium hexafluorophosphate was written by Kitamura, Mitsuru;Murakami, Kento;Shiratake, Yuichiro;Okauchi, Tatsuo. And the article was included in Chemistry Letters in 2013.Formula: C8H8ClNO This article mentions the following:

α-Arylcarboxylic acid amides were synthesized by reacting silyl enol ethers of aryl ketones and 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP). Silyl enol ethers react with ADMP to give N-(α-arylacyl)guanidines via the migration of aryl groups in enol ethers. The products were transformed to the corresponding α-aryl acetamides by treating with LiAlH₄. In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Formula: C8H8ClNO).

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Formula: C8H8ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics