One-pot synthesis of 1,2,4-oxadiazoles from chalcogen amino acid derivatives under microwave irradiation was written by Wolf, Lucas;Mayer, Joao C. P.;Quoos, Natalia;Sauer, Andre C.;Schwab, Ricardo S.;Rodrigues, Oscar E. D.;Dornelles, Luciano. And the article was included in Tetrahedron in 2021.Recommanded Product: 1,3-Dicyclohexylurea This article mentions the following:
A series of sulfur- and selenium-bearing, amino acid-derived 1,2,4-oxadiazoles were obtained by a simple procedure. The method consists of EDC-promoted coupling of chalcogen amino acid derivatives with arylamidoximes in acetone, followed by solvent removal and microwave irradiation in water medium. Influence of amidoxime substituents, of the chalcogen atom and of the amino acid side chain is discussed. The results showed this to be a fast, easy and effective method to obtain these compounds, with good functional-group tolerance, potentially favoring future applications in organic synthesis. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Recommanded Product: 1,3-Dicyclohexylurea).
1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: 1,3-Dicyclohexylurea
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics