Vachlioti, Eleanna et al. published their research in Journal of Chemical Crystallography in 2022 | CAS: 2387-23-7

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application of 2387-23-7

Synthesis, Spectroscopy and Crystal Structure Analysis of N1,N3-dicyclohexyl-N1-(all-trans-retinoyl)urea was written by Vachlioti, Eleanna;Kalantzi, Stefania;Papaioannou, Dionissios;Nastopoulos, Vassilios. And the article was included in Journal of Chemical Crystallography in 2022.Application of 2387-23-7 This article mentions the following:

The title compound, C33H50N2O2, was a side product in the reaction of all-trans-retinoic acid (atRA) with N-hydroxysuccinimide, in the presence of the coupling agent N,N’-dicyclohexylcarbodiimide, which produced the ‘active’ ester succinimidyl all-trans-retinoate as the product. It crystallized in the orthorhombic Pbca space group. The compound was characterized by 1H-NMR, 13C-NMR, ESI-MS and IR spectroscopy and its structure was determined by single-crystal X-ray diffraction. For example in the 13C-NMR spectrum, diagnostic peaks are those of the two amide carbonyl C atoms at δ 169.5 and 154.2 ppm, the ten olefinic C atoms of the unsaturated chain of atRA moiety at δ 149.0, 139.3, 137.7, 137.3, 134.9, 130.2, 130.0, 129.4, 128.5 and 121.5 ppm and the two methine C atoms of the N,N’-dicyclohexylurea moiety at δ 57.9 and 49.5 ppm. Detailed anal. of its mol. and supramol. structure showed that close-packing principles (elongated shape/large hydrophobic region of the mol.) together with chem. factors (N-H···O and C-H···O intermol. interactions) direct the 3D self-assembly process in the crystalline state. Hirshfeld surface anal. was employed, a powerful approach to quickly and easily gain insight into mol. environments in the crystalline state. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Application of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics