A Mild Heteroatom (O-, N-, and S-) Methylation Protocol Using Trimethyl Phosphate (TMP)-Ca(OH)2 Combination was written by Tang, Yu;Yu, Biao. And the article was included in Synthesis in 2022.Application In Synthesis of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide This article mentions the following:
A mild heteroatom methylation protocol using tri-Me phosphate (TMP)-Ca(OH)2 combination was developed, which proceeded in DMF, or water, or under neat conditions, at 80°C or at room temperature A series of O-, N-, and S-nucleophiles, including phenols, sulfonamides, N-heterocycles, such as 9H-carbazole, indole derivatives, and 1,8-naphthalimide, and aryl/alkyl thiols, were suitable substrates for this protocol. The high efficiency, operational simplicity, scalability, cost-efficiency, and environmentally friendly nature of this protocol made it an attractive alternative to the conventional base-promoted heteroatom methylation procedures. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Application In Synthesis of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide).
N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Application In Synthesis of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics