Schoellkopf, Ulrich et al. published their research in Justus Liebigs Annalen der Chemie in 1976 | CAS: 58644-54-5

N-Cyclopropylformamide (cas: 58644-54-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Category: amides-buliding-blocks

Syntheses with α-metalated isocyanides, XXXI. 2-Oxazolines from α-metalated isocyanides and carbonyl compounds. A new synthesis of β-amino alcohols was written by Schoellkopf, Ulrich;Gerhart, Fritz;Hoppe, Inga;Harms, Ruediger;Hantke, Kurt;Scheunemann, Karl D.;Eilers, Eberhard;Blume, Ernst. And the article was included in Justus Liebigs Annalen der Chemie in 1976.Category: amides-buliding-blocks This article mentions the following:

α-Metalated isocyanides MCRR1NC [R = H, Me, Ph; R1 = H, Me, Ph, 4-MeOC6H4, pyridyl, PhS, PhCH2S, 4-MeC6H4S; RR1 = (CH2)2, (CH2)5 M = Li, K], prepared from HCRR1NC and BuLi, KOCMe3, or Li tetramethylpiperidide in THF, reacted at ∼-70° with carbonyl compounds R2COR3 [ R2 = e.g., Ph, PhCH:CH, H, 4-F3CC6H4; R3 = H, Me, Ph; R2R3 = (CH2)5] to give adducts MOCR2R3CRR1NC (I), which are in equilibrium with 2-metalated oxazolines II. Addition of MeOH to the reaction mixture gave oxazolines III, which are readily hydrolyzed to give β-amine alcs. III are preferably lithiated with BuLi in the 2 position. Depending on the electrophile, trapping experiments gave derivatives of either I or II. In the experiment, the researchers used many compounds, for example, N-Cyclopropylformamide (cas: 58644-54-5Category: amides-buliding-blocks).

N-Cyclopropylformamide (cas: 58644-54-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics