Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure-activity relationship elucidation was written by Peters, Jens-Uwe;Luebbers, Thomas;Alanine, Alexander;Kolczewski, Sabine;Blasco, Francesca;Steward, Lucinda. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Synthetic Route of C7H7FN2O This article mentions the following:
The optimization of affinity and selectivity in a novel series of dual 5-HT5A/5-HT7 receptor ligands is described. Brain penetrant 2-aminodihydroquinazolines, such as I, with low nanomolar affinities were identified. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Synthetic Route of C7H7FN2O).
2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Synthetic Route of C7H7FN2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics