Asymmetric synthesis of isobenzofuranone derivatives and their unique character as protein kinase Cα (PKCα) activators was written by Hirai, Go;Ogoshi, Yosuke;Ohkubo, Megumi;Tamura, Yuki;Watanabe, Toru;Shimizu, Tadashi;Sodeoka, Mikiko. And the article was included in Tetrahedron Letters in 2009.Application In Synthesis of N,N-Diethylsalicylamide This article mentions the following:
An efficient enantioselective synthesis of conformationally constrained diacylglycerol analogs, 7-substituted isobenzofuranones, originally developed by the authors as PKCα ligands, was achieved by asym. dihydroxylation and γ-lactone formation via ortho-lithiation and carboxylation. A series of derivatives having straight and/or branched side-chains were synthesized and evaluated, and low-nanomolar-concentration affinity ligands and highly potent PKCα activators were found among them. These potent ligands induced phenotypic change of K562 cells, which is characteristic of PKC activators. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Application In Synthesis of N,N-Diethylsalicylamide).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application In Synthesis of N,N-Diethylsalicylamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics