CAN promoted synthesis of amide derivatives: a green technology for pharmaceuticals was written by Gupta, Neerja;Naaz, Ruby. And the article was included in International Journal of Pharma and Bio Sciences in 2010.Name: 2-(2-Chlorophenyl)acetamide This article mentions the following:
This method displays both economic and environmental advantages. High yields were achieved even on a gram scale, while reaction times are considerably shortened. Ceric ammonium nitrate (CAN) was found to be an efficient catalyst for the solid-phase green synthesis of carboxamides with urea in excellent yields under microwave irradiation Addnl., pharmaceutical applications of the amides were reviewed. In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Name: 2-(2-Chlorophenyl)acetamide).
2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Name: 2-(2-Chlorophenyl)acetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics