Directed ortho metalation of N,N-diethyl benzamides. Methodology and regiospecific synthesis of useful contiguously tri- and tetra-substituted oxygenated aromatics, phthalides and phthalic anhydrides was written by De Silva, S. O.;Reed, J. N.;Billedeau, R. J.;Wang, X.;Norris, D. J.;Snieckus, V.. And the article was included in Tetrahedron in 1992.Recommanded Product: N,N-Diethylsalicylamide This article mentions the following:
Full exptl. details for the directed ortho metalation approach to o-RC6H4CONEt2 (R = e.g., CO2H, CO2Me, CONEt2, CHO, OH, Br, F, organometallic) and contiguously 1,2,3- and 1,2,3,4-substituted benzamides, I and II (R = CHO, CO2H, OH), and III and IV [R = Me, (RR) = CH2; R1 = e.g., Me, CO2H] are given. The efficient conversion of benzamides I–IV (R or R1 = H) into phthalides (e.g., V; Z = H2) and phthalic anhydrides (e.g., V; Z = O), compounds previously available by demanding, classical methods, is detailed. A short synthesis of isoochracinic acid is described. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Recommanded Product: N,N-Diethylsalicylamide).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: N,N-Diethylsalicylamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics