Copper-Catalyzed Guanidinylation of Aryl Iodides: The Formation of N,N’-Disubstituted Guanidines was written by Cortes-Salva, Michelle;Nguyen, Be-Lan;Cuevas, Javier;Pennypacker, Keith R.;Antilla, Jon C.. And the article was included in Organic Letters in 2010.Safety of N,N-Diethylsalicylamide This article mentions the following:
A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N’-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive com. available guanidine salt and a series of aryl iodides together with copper iodide and N,N-diethylsalicylamide as an efficient catalyst/ligand system provided a simple diarylation procedure. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Safety of N,N-Diethylsalicylamide).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Safety of N,N-Diethylsalicylamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics