Potassium tert-butoxide-mediated metal-free synthesis of sulfonamides from sodium sulfinates and N,N-disubstituted formamides was written by Bao, Xiaodong;Rong, Xiaona;Liu, Zhiguo;Gu, Yugui;Liang, Guang;Xia, Qinqin. And the article was included in Tetrahedron Letters in 2018.Category: amides-buliding-blocks This article mentions the following:
A new protocol was developed for KO-t-Bu mediated metal-free direct S-N bond formation from sodium sulfinates and formamides as amine sources. This protocol provided a simple and green approach for the preparation of sulfonamide derivatives RSO2NR1R2 [R = 2-thienyl, Ph, 1-naphthyl, etc.; R1 = Me, Et, Bn; R2 = Me, Et; R1R2 = (CH2)5, (CH2)2O(CH2)2] from sodium sulfinates and N,N-disubstituted formamides. The reaction utilized readily available starting materials under metal-free conditions, thus providing an alternative and attractive route to sulfonamides. In the experiment, the researchers used many compounds, for example, 4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3Category: amides-buliding-blocks).
4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics