Stereoselective Synthesis of the γ-Lactam Hydrolysate of the Thiopeptide Cyclothiazomycin was written by Bagley, Mark C.;Xiong, Xin. And the article was included in Organic Letters in 2004.Related Products of 61189-99-9 This article mentions the following:
Chiral nonracemic thiazolylpropynone enamine I undergoing Bohlmann-Rahtz pyridine synthesis afforded a pyridine-containing γ-amino acid II in high optical purity that proceeded with total control of regiochem. and with minimal racemization. II was further modified to γ-lactam III, hydrolyzate of the macrocyclic thiopeptide antibiotic cyclothiazomycin, a selective renin inhibitor. Thus, III was synthesized in only four steps with 30% overall yield and 88% enantiomeric excess. In the experiment, the researchers used many compounds, for example, 2,2-Diethoxyacetamide (cas: 61189-99-9Related Products of 61189-99-9).
2,2-Diethoxyacetamide (cas: 61189-99-9) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 61189-99-9
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics