An Assessment of the Hypoglycemic and Antioxidant Properties of the Methanol Extract of Erythrophleum guineense Stem Bark in Albino Rats was written by Akande, Motunrayo Ganiyat;Nwinyi, Florence Chimezie;Egua, Maxwell Osaronowen;Ode, Julius Okwoche;Onakpa, Michael Monday;Mikail, Hudu Garba;Onoja, Samuel Okwudili;Mohammed, Adamu;Akumka, David Dezi. And the article was included in Journal of Herbs, Spices & Medicinal Plants in 2022.Name: 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide This article mentions the following:
Erythrophleum guineense G. Don is an enormous shade species that is indigenous to moist regions of Africa. Various forms of its bark are used to treat heart diseases, edema, headache, and body pains. In this study, the stem bark of Erythrophleum guineense was subjected to double maceration and extracted with 80methanol. The methanol extract was screened for its phytochem. components and in vitro antioxidant activity through the utilization of the Ferric Reducing/Antioxidant Power (FRAP) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity procedures. The acute toxicity of the plant extract was evaluated using Lorke’s method in albino rats. Screening was conducted in normoglycemic and glucose-challenged albino rats to determine the plant extract’s control of blood glucose levels. The doses of the methanol extract of Erythrophleum guineense tested in rats through the oral route were 100, 200, and 400 mg kg-1 body weights of the rats. The effects were compared with glibenclamide (0.2 mg kg-1 per os) and normal saline. The phytochem. constituents of the methanol extract of Erythrophleum guineense were saponins, terpenes, tannins, steroids, carbohydrates, and alkaloids. The results indicated that the plant extract possessed antioxidant and hypoglycemic properties. Further research is warranted to isolate the active hypoglycemic principle of the stem bark of Erythrophleum guineense. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Name: 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide).
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Name: 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics