Yang, Peng published the artcileBiodegradable polycaprolactone metallopolymer-antibiotic bioconjugates containing phenylboronic acid and cobaltocenium for antimicrobial application, Formula: C16H20BNO3, the publication is Biomaterials Science (2021), 9(21), 7237-7246, database is CAplus and MEDLINE.
This paper reports antimicrobial metallopolymers containing biodegradable polycaprolactone as the backbone with boronic acid and cobaltocenium as the side chain. While boronic acid promotes interactions with bacterial cells via boronolectin with lipopolysaccharides, cationic cobaltocenium facilitates the unique complexation with anionic β-lactam antibiotics. The synergistic interactions in these metallopolymer-antibiotic bioconjugates were evidenced by re-sensitized efficacy of penicillin-G against four different Gram-neg. bacteria (E. coli, P. vulgaris, P. aeruginosa and K. pneumoniae). The degradability of the polyester backbone was validated through tests under physiol. pH (7.4) and acidic pH (5.5) or under enzymic conditions. These metallopolymers exhibited time-dependent uptake and reduction of cobalt metals in different organs of mice via in vivo absorption, distribution, metabolism, and excretion (ADME) tests.
Biomaterials Science published new progress about 1357387-28-0. 1357387-28-0 belongs to amides-buliding-blocks, auxiliary class Alkynyl,Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronate Esters,, name is N-(Prop-2-yn-1-yl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide, and the molecular formula is C6H6N2O, Formula: C16H20BNO3.
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https://en.wikipedia.org/wiki/Amide,
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