Wang, Min published the artcileApolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways, Related Products of amides-buliding-blocks, the publication is Molecular Medicine Reports (2019), 19(2), 1272-1283, database is CAplus and MEDLINE.
Apolipoprotein M (ApoM) is a type of apolipoprotein. It is well known that high-d. lipoprotein (HDL) decreases inflammatory responses via the apoM-sphingosine-1-phosphate (S1P) pathway. The present study further investigated the importance of ApoM in the inhibitory effects of HDL on inflammation. Furthermore, cell culture experiments were performed using a permanent human hybrid endothelial cell line (EA.hy926). In cell culture experiments, when cells were pre-cultured with rec-apoM or were engineered to overexpress apoM (apoMTg), they exhibited decreased expression levels of IL-1beta and MCP-1 following TNF-a treatment compared with in normal apoM-expressing cells (apoMTgN) Furthermore, the mRNA expression levels of IL-1beta and MCP-1 were significantly elevated following addition of the S1PR1 inhibitor W146, but not by the scavenger receptor class B type I inhibitor, block lipid transport-1 (BLT-1), in apoMTg cells prior to TNF-a treatment. Conversely, there were no differences in these inflammatory biomarkers under the same conditions in apoMTgN cells. The mRNA expression levels of DHCR24 were significantly reduced by the addition of BLT-1 prior to TNF-a treatment in apoMTg cells; however, there was no difference in the expression of this inflammatory biomarker in apoMTgN cells. In conclusion, ApoM displayed inhibitory effects against the inflammatory response in vivo and in vitro; these effects may be induced via the S1PR1 and DHCR24 pathways.
Molecular Medicine Reports published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C8H8O3, Related Products of amides-buliding-blocks.
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