Thompson, Mark J. published the artcileImproved 2,4-Diarylthiazole-Based Antiprion Agents: switching the Sense of the Amide Group at C5 Leads to an Increase in Potency, COA of Formula: C8H9NOS, the publication is ChemMedChem (2010), 5(9), 1476-1488, database is CAplus and MEDLINE.
Amide derivatives of 2,4-diarylthiazole-5-carboxylic acids were synthesized and tested for efficacy in a cell line model of prion disease. A number of compounds demonstrating antiprion activity were thereby identified from the screening libraries, showing improved potency and reproducibility of results relative to amide derivatives of the related 2,4-diphenyl-5-aminothiazole, which have been documented previously. Thus, ‘switching’ the sense of the amide bond at thiazole C5 revealed a more promising lead series of potential prion disease therapeutics. Furthermore, 3,5-diaryl-1,2,4-thiadiazoles isolated as byproducts during library synthesis provided a handful of addnl. examples possessing an antiprion effect, thereby augmenting the set of newly identified active compounds Evaluation of binding to cellular prion protein (PrPC) showed only weak affinities at best, suggesting that the newly identified antiprion agents do not mediate their biol. effect through direct interaction with PrPC.
ChemMedChem published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C7H11N, COA of Formula: C8H9NOS.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics