Spahn, Nathan A. published the artcileRegioselective Iron-Catalyzed [2 + 2 + 2] Cycloaddition Reaction Forming 4,6-Disubstituted 2-Aminopyridines from Terminal Alkynes and Cyanamides, Recommanded Product: N,N-Dibenzylcyanamide, the publication is Journal of Organic Chemistry (2017), 82(1), 234-242, database is CAplus and MEDLINE.
Fe complexes bound by redox-active pyridine dialdimine (PDAI) ligands catalyze the cycloaddition of two terminal alkynes and one cyanamide. The reaction is both chemo- and regioselective as only 4,6-disubstituted-2-aminopyridine products are formed in moderate to high yields. Isolation of a Fe-azametallacycle (4) suggests catalyst deactivation occurs with large excess of cyanamide over longer reaction times. Fe-catalyzed cycloaddition allowed for a straightforward synthesis of a variety of amino-pyridines, including known estrogen receptor ligands.
Journal of Organic Chemistry published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C9H8BNO2, Recommanded Product: N,N-Dibenzylcyanamide.
Referemce:
https://en.wikipedia.org/wiki/Amide,
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