Saravanan, Janardhanan published the artcileSynthesis of some 3-substituted amino-4,5-tetramethylene thieno[2,3-d][ 1,2,3]-triazin-4(3H)-ones as potential antimicrobial agents, Formula: C5H8N2O, the publication is European Journal of Medicinal Chemistry (2010), 45(9), 4365-4369, database is CAplus and MEDLINE.
3-Substituted 4,5-tetramethylene thieno[2,3-d][1,2,3]-triazin-4(3H)-ones I have been synthesized from cyclohexanone and N-substituted 2-cyanoacetamides via the Gewald reaction followed by diazotization. Compounds I were evaluated for their antimicrobial activity by the agar diffusion method against four bacteria and three fungi, with Ampicillin and Miconazole nitrate as standards I (R = 4-FC6H4 and 2-, 3-, and 4-ClC6H4) showed an antimicrobial efficacy considerably greater than the compounds with hydrogen, Ph, and electron donating (activating) R groups like Me, Et, and tolyl. This suggests that lipophillic groups like chloro and fluoro substituted on the Ph ring play an important role in enhancing the antimicrobial properties of this class of compounds From the screening results it is shown that the compounds having lipophillic R groups like chlorophenyl and fluorophenyl exhibit appreciable antimicrobial activities.
European Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics