Peterson, Randall T. published the artcileSmall molecule developmental screens reveal the logic and timing of vertebrate development, HPLC of Formula: 321673-30-7, the publication is Proceedings of the National Academy of Sciences of the United States of America (2000), 97(24), 12965-12969, database is CAplus and MEDLINE.
Much has been learned about vertebrate development by random mutagenesis followed by phenotypic screening and by targeted gene disruption followed by phenotypic anal. in model organisms. Because the timing of many developmental events is critical, it would be useful to have temporal control over modulation of gene function, a luxury frequently not possible with genetic mutants. Here, the authors used synthetic small mols. from the DiverSet E obtained from Chembridge Corp., to demonstrate that small mols. capable of conditional gene product modulation can be identified through developmental screens in zebrafish. The authors have identified several small mols. that specifically modulate various aspects of vertebrate ontogeny, including development of the central nervous system, the cardiovascular system, the neural crest, and the ear. Several of the small mols. identified allowed the authors to dissect the logic of melanocyte and otolith development and to identify critical periods for these events. Small mols. identified in this way offer potential to dissect further these and other developmental processes and to identify novel genes involved in vertebrate development.
Proceedings of the National Academy of Sciences of the United States of America published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, HPLC of Formula: 321673-30-7.
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