Paul, Bhaskar published the artcileCobalt Catalyzed N-Methylation of Amides using Methanol, HPLC of Formula: 1453-82-3, the publication is Asian Journal of Organic Chemistry (2022), 11(1), e202100678, database is CAplus.
N-Methylation of amides with methanol is reported in the presence of an in-situ generated cobalt catalyst. With this simple protocol, various amides were methylated in up to 99% yield. Notably, the involvement of active cobalt (I) hydride in this methylation process was revealed by control experiments Deuterium labeling studies were carried out using methanol-d4, taking benzamide and the possible intermediate N-(hydroxymethyl)benzamide to understand this transformation. Addnl., DFT calculations for the amide-formaldehyde coupling were performed to elucidate the influence of catalyst in this step.
Asian Journal of Organic Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, HPLC of Formula: 1453-82-3.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics