Mijin, Dusan Z. published the artcileSynthesis of substituted 3-cyano-2-pyridones. Part IV. Influence of 3-alkyl-2,4-pentanedione and N-alkylcyanoacetamide structure on the enzyme-catalyzed synthesis of substituted 3-cyano-2-pyridones, SDS of cas: 15029-36-4, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2006), 45B(4), 993-1003, database is CAplus.
Lipase from Candida rugosa was used to study the influence of 3-alkyl-2,4-pentanedione and N-alkylcyanoacetamide structure on the enzyme-catalyzed reaction of pyridone ring formation in water at 40°. Starting with 1,3-diketones and cyanoacetamides and for comparison, the expected corresponding 3-cyano-2-pyridones were synthesized by chem. methods. Bulkier substituents lower the initial reaction rate of the enzyme-catalyzed reactions and consequently the yield of the corresponding pyridones. N-alkylcyanoacetamides are more reactive in comparison to the corresponding 3-alkyl-2,4-pentanediones with respect to the obtained yields of 3-cyano-2-pyridones.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, SDS of cas: 15029-36-4.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics