Drsata, J. published the artcileSide effects of potential antituberculotics. Part 10. Parabolic model of the relation between electronic parameters and the hepatotoxicity of thiobenzaamides, COA of Formula: C8H9NOS, the publication is Pharmazie (1985), 40(11), 809-10, database is CAplus and MEDLINE.
Thirteen thiobenzamides (I; R = H, Br, Cl, OMe, Me, NO2, or SMe) which do not undergo metabolic reduction were given to rats (0.73 mmol/kg, orally), and the hepatotoxicity (as measured by serum alanine aminotransferase) was plotted against the Hammett σ-constant There was a parabolic relation: with increasing Hammett values the liver toxicity initially decreased and then increased. All I had some hepatotoxicity.
Pharmazie published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, COA of Formula: C8H9NOS.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics