Cohen, Yifat published the artcileMechanisms of absorption of vitamin D3 delivered in protein nanoparticles in the absence and presence of fat, Category: amides-buliding-blocks, the publication is Food & Function (2021), 12(11), 4935-4946, database is CAplus and MEDLINE.
Novel protein-based nanovehicles offer alternatives to fat for delivery of lipophilic bioactives (nutraceuticals and drugs), yet they raise important questions regarding the bioavailability and absorption mechanism of the bioactive without fat. To provide answers, we chose vitamin D3 (VD3) as a model lipophilic-nutraceutical, re-assembled casein-micelles (rCM) as model protein-based nanovehicles, and non-fat yoghurt as a model food. We prepared three yoghurt formulations: 3% fat with D3 dissolved in milk-fat, non-fat and 3% fat, both latter enriched with VD3 within rCM. Following in vitro digestion, D3 retention and bioaccessibility were high (∼90% and ∼70%, resp.) in all formulations. VD3 uptake by Caco-2 cells was three-fold higher (p < 0.005) in the non-fat yoghurt enriched with VD3 in rCM compared with enriched fat-containing yoghurts. SR-BI, CD36 and NPC1L1 transporters were involved in VD3 absorption irresp. of the composition Thus, our findings demonstrate that protein nanovehicles may improve D3 bioavailability, without altering its absorption mechanism compared to that from fat.
Food & Function published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Category: amides-buliding-blocks.
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