Coeck, Robin published the artcileGold and Silver-Catalyzed Reductive Amination of Aromatic Carboxylic Acids to Benzylic Amines, Safety of Isonicotinamide, the publication is ACS Catalysis (2021), 11(13), 7672-7684, database is CAplus.
The reductive amination of benzoic acid and its derivatives was an effective addition to current synthesis methods for benzylamine. However, with current technol. it was very difficult to keep the aromaticity intact when starting from benzoic acid, and salt wastes were often generated in the process. Here, a heterogeneous catalytic system for such a reductive amination, requiring solely H2 and NH3 as the reactants was reported. The Ag/TiO2 or Au/TiO2 catalysts can be used multiple times, and very little noble metal was required, only 0.025 mol % Au. The catalysts were bifunctional: the support catalyzes the dehydration of both the ammonium carboxylate to the amide and of the amide to the nitrile, while the sites at the metal-support interface promote the hydrogenation of the in situ generated nitrile. Yields of up to 92% benzylamine were obtained.
ACS Catalysis published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Safety of Isonicotinamide.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics